IL-15

• Description :

  IL-15 is an immunomodulating cytokine that stimulates the proliferation of T lymphocytes and shares many biological properties with IL-2. IL-15 exerts its biological activites primarily on T cells. It is also essential in the development, survival and activation of NK cells. Increased expression of IL-15 has been implicated with rheumatoid arthritis, inflammatory bowl disease and diseases affiliated with retroviruses HIV and HTLV-I. Human IL-15 is biologically active on mouse cells as measured by the dose-dependent stimulation of the proliferation of mouse CTLL cells. Recombinant human IL-15 is a 12.9 kDa protein consisting of 115 amino acid residues.

• Synonyms :

  IL15; IL-15

• NCBI Gene ID :

  3600

• UniProt :

  P40933

• Accession Number :

  NP_000576.1

• Accession Number mRNA :

  NM_000585.4

• Chromosomal Location :

  4q31

• Reactivity :

  Human

• Cross Reactivity :

  Monkey, Mouse, Human, Rat, Cow

• Sequence :

  MNWVNVISDL KKIEDLIQSM HIDATLYTES DVHPSCKVTA MKCFLLELQV ISLESGDASI HDTVENLIIL ANNSLSSNGN VTESGCKECE ELEEKNIKEF LQSFVHIVQM FINTS

• Endotoxin :

  < 0.1 ng/µg of protein (< 1EU/µg)

• Purity :

  > 98% by SDS-PAGE & HPLC analyses

• Bioactivity :

  The ED50 as determined by the dose-dependent stimulation of the proliferation of CTLL-2 cells was found to be ≤ 0.5 ng/ml, corresponding to a specific activity of ≥ 2 x 106 units/mg.

• Length :

  114

• Form :

  Lyophilized

• Buffer :

  20 mM NaP pH 8.5

• Molecular Weight :

  12.9 kDa

• Host or Source :

  E. coli