IL-15

• Description:

  IL-15 is an immunomodulating cytokine that stimulates the proliferation of T lymphocytes and shares many biological properties with IL-2. IL-15 exerts its biological activites primarily on T cells. It is also essential in the development, survival and activation of NK cells. Increased expression of IL-15 has been implicated with rheumatoid arthritis, inflammatory bowl disease and diseases affiliated with retroviruses HIV and HTLV-I. Human IL-15 is biologically active on mouse cells as measured by the dose-dependent stimulation of the proliferation of mouse CTLL cells. Recombinant human IL-15 is a 12.9 kDa protein consisting of 115 amino acid residues.

• Synonyms:

  IL15; IL-15

• NCBI Gene ID:

  3600

• UniProt:

  P40933

• Accession Number:

  NP_000576.1

• Accession Number mRNA:

  NM_000585.4

• Chromosomal Location:

  4q31

• Reactivity:

  Human

• Cross Reactivity:

  Monkey, Mouse, Human, Rat, Cow

• Sequence:

  MNWVNVISDL KKIEDLIQSM HIDATLYTES DVHPSCKVTA MKCFLLELQV ISLESGDASI HDTVENLIIL ANNSLSSNGN VTESGCKECE ELEEKNIKEF LQSFVHIVQM FINTS

• Endotoxin:

  < 0.1 ng/µg of protein (< 1EU/µg)

• Purity:

  > 98% by SDS-PAGE & HPLC analyses

• Bioactivity:

  The ED50 as determined by the dose-dependent stimulation of the proliferation of CTLL-2 cells was found to be ≤ 0.5 ng/ml, corresponding to a specific activity of ≥ 2 x 106 units/mg.

• Length:

  114

• Form:

  Lyophilized

• Buffer:

  20 mM NaP pH 8.5

• Molecular Weight:

  12.9 kDa

• Host or Source:

  E. coli