IGF-BP5

• Description:

  IGF-BP5 is a member of the insulin-like growth factor binding protein (IGF-BP) family and encodes a protein with an IGFBP domain and a thyroglobulin type-I domain. The protein forms a ternary complex with insulin-like growth factor acid-labile subunit (IGFALS) and either insulin-like growth factor (IGF) I or II. In this form, it circulates in the plasma, prolonging the half-life of IGFs and altering their interaction with cell surface receptors. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.

• Synonyms:

  IGFBP5; IBP5

• NCBI Gene ID:

  3488

• UniProt:

  P24593

• Accession Number:

  NP_000590.1

• Accession Number mRNA:

  NM_000599

• Chromosomal Location:

  2q33-q36

• Reactivity:

  Human

• Cross Reactivity:

  Human

• Sequence:

  MLGSFVHCEP CDEKALSMCP PSPLGCELVK EPGCGCCMTC ALAEGQSCGV YTERCAQGLR CLPRQDEEKP LHALLHGRGV CLNEKSYREQ VKIERDSREH EEPTTSEMAE ETYSPKIFRP KHTRISELKA EAVKKDRRKK LTQSKFVGGA ENTAHPRIIS APEMRQESEQ GPCRRHMEAS LQELKASPRM VPRAVYLPNC DRKGFYKRKQ CKPSRGRKRG ICWCVDKYGM KLPGMEYVDG DFQCHTFDSS NVS

• Endotoxin:

  < 0.1 ng/µg of protein (< 1EU/µg)

• Purity:

  > 98% by SDS-PAGE & HPLC analyses

• Bioactivity:

  The ED50 was determined by its ability to inhibit IGF-II induced proliferation of MCF-7 is ≤ 0.3 μg/ml in the presence of 15 ng/ml of human IGF-II.

• Length:

  253

• Form:

  Lyophilized

• Molecular Weight:

  28.6 kDa

• Host or Source:

  E. coli