RegisterLogin

FRP-5, soluble

CAT: 0209-S01-077-L500Size: 500 µgDry Ice: NoHazardous: No
CAT#:0209-S01-077-L500Size:500 µg
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Description
Secreted Frizzled Related Proteins (sFRPs) are a family of glycosylated Wnt antagonists that inhibit Wnt signaling, either by directly binding to Wnt proteins to prevent their binding to Frizzled (Fz) family receptor proteins or by forming non‐functional interactions with Frizzled receptors. sFRPs share homology with the cysteine‐rich, extracellular domain of Frizzled proteins. sFRP‐5 is secreted in a variety of embryonic and adult tissues. During embryonic development, sFRP‐5 regulates formation of the retina, brain, trunk, foregut, anterior visceral endoderm, and epithelial structures through Wnt and BMP inhibition. In adults, sFRP‐5 is expressed by adipocytes, particularly in white adipose tissue, and acts as an anti‐inflammatory adipokine. Shown to improve metabolic function and reduce adipose tissue inflammation, sFRP‐5 also acts in a cardio‐protective manner after ischemia and reperfusion injury in the heart, suppressing the non‐canonical Wnt5a/JNK signaling pathway in macrophages and myocytes. sFRP‐5 levels are negatively correlated with obesity‐related disorders including insulin resistance, type 2 diabetes, dyslipidemia, atherosclerosis, and coronary artery disease. Downregulation by promoter hypermethylation is observed in numerous cancers including gastric, cervical, hepatocellular carcinoma, pancreatic, oral squamous cell, breast, colon, bladder, and renal. sFRP‐5 inhibits melanogenesis when expressed in vitiligo melanocytes. CHO cell‐derived Recombinant Human sFRP5 is a 288‐amino‐acid length glycoprotein with a calculated molecular weight of 32.7 kDa; however, due to glycosylation, protein migration occurs at an apparent molecular weight of approximately 33‐35 kDa by SDS‐PAGE analysis under both reducing and non‐reducing conditions.
Synonyms
Secreted frizzled‐related protein 5, Frizzled‐related protein 1b, FRP‐1b, Secreted apoptosis‐related protein 3, SARP‐3
NCBI Gene ID
6425
UniProt
Q5T4F7
Accession Number
NP_003006.2
Accession Number mRNA
NM_003015.3
Chromosomal Location
10q24.2
Reactivity
Human
Sequence
EEYDYYGWQA EPLHGRSYSK PPQCLDIPAD LPLCHTVGYK RMRLPNLLEH ESLAEVKQQA SSWLPLLAKR CHSDTQVFLC SLFAPVCLDR PIYPCRSLCE AVRAGCAPLM EAYGFPWPEM LHCHKFPLDN DLCIAVQFGH LPATAPPVTK ICAQCEMEHS ADGLMEQMCS SDFVVKMRIK EIKIENGDRK LIGAQKKKKL LKPGPLKRKD TKRLVLHMKN GAGCPCPQLD SLAGSFLVMG RKVDGQLLLM AVYRWDKKNK EMKFAVKFMF SYPCSLYYPF FYGAAEPH
Endotoxin
< 0.1 ng/µg of protein (< 1EU/µg)
Purity
≥ 98% by SDS-PAGE gel and HPLC analyses
Bioactivity
Determined by its ability to decrease alkaline phosphatase activity in CCL-226 cells when treated with 25 ng/ml of Murine Wnt-3a.
Length
288
Form
Lyophilized
Molecular Weight
32.7 kDa
Host or Source
CHO cells

Related Products

CatalogName
S01-070-L250FRP-1, soluble
S01-075SFRP-4, soluble
S01-070-L500FRP-1, soluble
S01-070FRP-1, soluble
S01-075FRP-4, soluble
S01-070SFRP-1, soluble
S01-070-L1000FRP-1, soluble
S01-075-L1000FRP-4, soluble
S01-070-L100FRP-1, soluble
S01-075-L100FRP-4, soluble

Alternative Products

CatalogName
MBS692862-01Human FRP-5, soluble
MBS692513-01Human FRP-4, soluble
MBS692283-01Human FRP-1, soluble
B2012712Alkali-soluble Casein (5%)
GWB-9D1EEAADENOVIRUS TYPE 5 SOLUBLE ANTIGEN
A0880-03KADENOVIRUS TYPE 5 SOLUBLE ANTIGEN discontinued
GTR10466452Rat Soluble scavenger protein with 5 SRCR domains
GTR10375302Porcine Soluble scavenger protein with 5 SRCR domains
GTR10396906Rabbit Soluble scavenger protein with 5 SRCR domains
GTR10386725Chicken Soluble scavenger protein with 5 SRCR domains

Popular Products