Endostatin

• Description :

  Endostatin is a naturally occurring 20 kDa polypeptide derived from the C-terminal portion of type XVIII collagen. It functions as an anti-angiogenic cytokine that is expressed in various organs with the highest levels in liver, lung and kidney. Endostatin inhibits angiogenesis by blocking the pro-angiogenic activities of VEGF and FGF-basic. Recombinant human Endostatin is a 20.2 kDa protein consisting 184 amino acid residues.

• Synonyms :

  COL18A1; KS; KNO; KNO1

• NCBI Gene ID :

  80781

• UniProt :

  P39060

• Accession Number :

  NP_085059

• Accession Number mRNA :

  NM_030582

• Chromosomal Location :

  21q22.3

• Reactivity :

  Human

• Cross Reactivity :

  Human

• Sequence :

  MHSHRDFQPV LHLVALNSPL SGGMRGIRGA DFQCFQQARA VGLAGTFRAF LSSRLQDLYS IVRRADRAAV PIVNLKDELL FPSWEALFSG SEGPLKPGAR IFSFDGKDVL RHPTWPQKSV WHGSDPNGRR LTESYCETWR TEAPSATGQA SSLLGGRLLG QSAASCHHAY IVLCIENSFM TASK

• Endotoxin :

  < 0.1 ng/µg of protein (< 1EU/µg)

• Purity :

  98% by SDS-PAGE & HPLC analyses

• Bioactivity :

  Measured by its ability to inhibit HUVEC migration.

• Length :

  184

• Form :

  Lyophilized

• Molecular Weight :

  20.2 kDa

• Host or Source :

  E. coli