Chemerin

• Description:

  Chemerin is a secreted chemoattractant protein that can signal through the chemokine like receptor-1 (CMKLR1) . It is expressed in various tissues, including white adipose tissue, and circulates in blood as an inactive 143 amino acid precursor protein. Biologically active Chemerin is generated by proteolytic removal of C-terminal residues by several circulating proteases. Chemerin acts as a chemoattractant for cells expressing the CMKLR1 receptor, which includes certain dendritic cells, macrophages, and adipocytes. Recombinant human Chemerin is a 15.6 kDa protein consisting of 135 amino acid residues.

• Synonyms:

  RARRES2; TIG2; HP10433

• NCBI Gene ID:

  5919

• UniProt:

  Q99969

• Accession Number:

  NP_002880.1

• Accession Number mRNA:

  NM_002889.3

• Chromosomal Location:

  7q36.1

• Reactivity:

  Human

• Cross Reactivity:

  Human

• Sequence:

  ELTEAQRRGL QVALEEFHKH PPVQWAFQET SVESAVDTPF PAGIFVRLEF KLQQTSCRKR DWKKPECKVR PNGRKRKCLA CIKLGSEDKV LGRLVHCPIE TQVLREAEEH QETQCLRVQR AGEDPHSFYF PGQFA

• Endotoxin:

  < 0.1 ng/µg of protein (< 1EU/µg)

• Purity:

  > 98% by SDS-PAGE & HPLC analyses

• Bioactivity:

  Determined by its ability to chemoattract human immature dendritic cells using a concentration range of 1.0-100 ng/ml.

• Length:

  135

• Form:

  Lyophilized

• Molecular Weight:

  15.6 kDa

• Host or Source:

  E. coli