Betacellulin

• Description:

  Betacellulin is an EGF-related polypeptide growth factor that signals through the EGF receptor. It is produced in several tissues, including the pancreas, small intestine, and in certain tumor cells. Betacellulin is a potent mitogen for retinal pigment epithelial cells and vascular smooth muscle cells. Human Betacellulin is initially synthesized as a glycosylated 32.0 kDa transmembrane precursor protein, which is processed by proteolytic cleavage to produce the mature sequence. Recombinant human Betacellulin is a 9.0 kDa monomeric protein, containing 80 amino residues, which comprises the mature EGF homologous portion of the Betacellulin protein.

• Synonyms:

  BTC

• NCBI Gene ID:

  685

• UniProt:

  P35070

• Accession Number:

  NP_001720

• Accession Number mRNA:

  NM_001729

• Chromosomal Location:

  4Q13-q21

• Reactivity:

  Human

• Cross Reactivity:

  Mouse, Human

• Sequence:

  DGNSTRSPET NGLLCGDPEE NCAATTTQSK RKGHFSRCPK QYKHYCIKGR CRFVVAEQTP SCVCDEGYIG ARCERVDLFY

• Endotoxin:

  < 0.1 ng/µg of protein (< 1EU/µg)

• Purity:

  >98% by SDS-PAGE & HPLC analyses

• Bioactivity:

  The ED50 was determined by the dose-dependent stimulation of the proliferation of murine Balb/3T3 cells is ≤ 0.05 ng/ml, corresponding to a specific activity of ≥ 2 x 107 units/mg.

• Length:

  80

• Form:

  Lyophilized

• Molecular Weight:

  9.0 kDa

• Host or Source:

  E. coli