Betacellulin

CAT: 0209-100-332-L250Size: 250 µgDry Ice: NoHazardous: No
CAT#:0209-100-332-L250Size:250 µg
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Description
Betacellulin is an EGF-related polypeptide growth factor that signals through the EGF receptor. It is produced in several tissues, including the pancreas, small intestine, and in certain tumor cells. Betacellulin is a potent mitogen for retinal pigment epithelial cells and vascular smooth muscle cells. Human Betacellulin is initially synthesized as a glycosylated 32.0 kDa transmembrane precursor protein, which is processed by proteolytic cleavage to produce the mature sequence. Recombinant human Betacellulin is a 9.0 kDa monomeric protein, containing 80 amino residues, which comprises the mature EGF homologous portion of the Betacellulin protein.
Synonyms
BTC
NCBI Gene ID
685
UniProt
P35070
Accession Number
NP_001720
Accession Number mRNA
NM_001729
Chromosomal Location
4Q13-q21
Reactivity
Human
Cross Reactivity
Mouse, Human
Sequence
DGNSTRSPET NGLLCGDPEE NCAATTTQSK RKGHFSRCPK QYKHYCIKGR CRFVVAEQTP SCVCDEGYIG ARCERVDLFY
Endotoxin
< 0.1 ng/µg of protein (< 1EU/µg)
Purity
>98% by SDS-PAGE & HPLC analyses
Bioactivity
The ED50 was determined by the dose-dependent stimulation of the proliferation of murine Balb/3T3 cells is ≤ 0.05 ng/ml, corresponding to a specific activity of ≥ 2 x 107 units/mg.
Length
80
Form
Lyophilized
Molecular Weight
9.0 kDa
Host or Source
E. coli

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