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BDNF (Animal Free)

CAT: 0209-100-005-L250-AFSize: 250 µgDry Ice: NoHazardous: No
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CAT#:0209-100-005-L250-AFSize:250 µg
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Description
BDNF is a member of the NGF family of neurotrophic growth factors. Like other members of this family, BDNF supports neuron proliferation and survival. BDNF can bind to a low affinity cell surface receptor called LNGFR, which also binds other neurotrophins such as NGF, NT-3 and NT-4. However, BDNF mediates its neurotrophic properties by signaling through a high affinity cell surface receptor called gp145/trkB. BDNF is expressed as the C-terminal portion of a 247 amino acid polypeptide precursor, which also contains a signal sequence of 18 amino acid residues and a propeptide of 110 amino acid residues. Recombinant Human/Murine/Rat BDNF is a 27.0 kDa homodimer of two 120 amino acid subunits linked by strong non-covalent interactions.
Synonyms
BDNF
NCBI Gene ID
627
UniProt
P23560
Accession Number
NP_733931.1
Accession Number mRNA
NM_170735.5
Chromosomal Location
11p13
Reactivity
Human/Murine/Rat
Cross Reactivity
Chicken, Frog, Guinea Pig, Hamster, Monkey, Mouse, Rat, Human, Tadpole
Sequence
MHSDPARRGE LSVCDSISEW VTAADKKTAV DMSGGTVTVL EKVPVSKGQL KQYFYETKCN PMGYTKEGCR GIDKRHWNSQ CRTTQSYVRA LTMDSKKRIG WRFIRIDTSC VCTLTIKRGR
Endotoxin
< 0.01 ng/µg of protein (< 0.1 EU/µg)
Purity
≥ 98% by SDS-PAGE gel and HPLC analyses.
Bioactivity
Determined by its ability to bind recombinant human TrkB Fc Chimera in a functional ELISA.
Length
119
Form
Lyophilized
Molecular Weight
27.0 kDa
Host or Source
E.coli

UniProtKB · P23560

Neurotrophic factor BDNF precursor form

BDNF_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P23560
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
BDNF
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
proBDNF
EC number
—
Processing
Precursor
Secondary accessions
A7LA85, A7LA92, D3DQZ2, Q598Q1, Q6DN19, Q6YNR2, Q6YNR3, Q9BYY7, Q9UC24
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

Coding sequence diversity

Alternative promoter usageAlternative splicing

PTM

Cleavage on pair of basic residuesDisulfide bondGlycoprotein

Molecular function

Growth factor

Cellular component

Secreted

Domain

Signal

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Alternative Products

CatalogName
HY-P700158AF-01Animal-Free BDNF, Human (His)
BT-BDNF-AFL-025Recombinant Human BDNF Protein Animal-Free
MBS692868-01Human/Murine/Rat BDNF (Animal Free)
PRP1066-01Human/Mouse/Rat BDNF protein, His tag (Animal-Free)
208602BDNF, Recombinant, Human, Animal Free (Brain Derived Neurotrophic Factor) discontinued
GTR18895280-01Recombinant BDNF (Brain-derived neurotrophic factor), Human/Mouse, Animal-Free
C-CYP350-5ugRecombinant Human/Mouse/Rat BDNF / Brain-Derived Neurotrophic Factor, Animal Free & Carrier Free
CS-BDNF-100-2Recombinant BDNF (Human/Mouse/Rat), Animal-Free, E. coli, RUO, 100μg
CS-BDNF-10-2Recombinant BDNF (Human/Mouse/Rat), Animal-Free, E. coli, RUO, 10μg
CS-BDNF-1000-2Recombinant BDNF (Human/Mouse/Rat), Animal-Free, E. coli, RUO, 1000μg

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