2-Chlorohexadecanoic acid

CAT: 0804-HY-131688-01Size: 1 mgDry Ice: NoHazardous: No
CAT#:0804-HY-131688-01Size:1 mg
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Description
2-Chlorohexadecanoic acid, an inflammatory lipid mediator, interferes with protein palmitoylation, induces ER-stress markers, reduced the ER ATP content, and activates transcription and secretion of IL-6 as well as IL-8.2-Chlorohexadecanoic acid disrupts the mitochondrial membrane potential and induces procaspase-3 and PARP cleavage.2-Chlorohexadecanoic acid can across blood-brain barrier (BBB) and compromises ER- and mitochondrial functions in the human brain endothelial cell line hCMEC/D3[1].
CAS Number
[19117-92-1]
UNSPSC
12352211
Target
Caspase; PARP
Type
Reference compound
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Epigenetics
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/2-chlorohexadecanoic-acid.html
Purity
99.88
Solubility
DMSO : 20 mg/mL (ultrasonic)
Smiles
CCCCCCCCCCCCCCC(Cl)C(O)=O
Molecular Formula
C16H31ClO2
Molecular Weight
290.87
References & Citations
[1]Eva Bernhart, et al. 2-Chlorohexadecanoic acid induces ER stress and mitochondrial dysfunction in brain microvascular endothelial cells. Redox Biol. 2018 May;15:441-451.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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