Recombinant Glutamate receptor 3 Monoclonal Antibody

• Background:

  AMPA receptors (AMPARs) are comprised of four subunits (GluR 1-4) that assemble as homo- or hetero-tetramers and mediate the majority of fast excitatory transmissions in the CNS. AMPARs are implicated in synapse formation, stabilization and plasticity. Glutamate receptor 3 (GluR3) knockout mice exhibited normal basal synaptic transmission and long-term depression (LTD) but enhanced long-term potentiation (LTP) . In contrast, GluR 2/3 double knockout mice are impaired in basal synaptic transmission. Aberrant GluR3 expression or activity is implicated in a number of diseases, including autoimmune epilepsy, X-linked mental retardation, Rett's syndrome, amyotrophic lateral sclerosis and Alzheimer disease.

• Abbreviation:

  Glutamate receptor 3

• UniProt:

  P42263

• Host:

  Rabbit

• Reactivity:

  Rat; Mouse

• Immunogen:

  Recombinant human Glutamate receptor 3 fragment

• Target:

  MRX; GRIA; GLUR; GluA; GLUR-K; GRIA3; GLUR-C; GLUR-K3; GLUR3; GLURC; GluA3; MRX94; AMPA 3; AMPA selective glutamate receptor 3; AMPA-selective glutamate receptor 3; dJ1171F9.1; GLUK3; GluR 3; GLUR C; GLUR K3; GluR-3; Glutamate ionotropic receptor AMPA type subunit 3; Glutamate receptor; Glutamate receptor 3; Glutamate receptor C; Glutamate receptor ionotrophic AMPA 3; Glutamate receptor ionotropic; Glutamate receptor subunit 3; GRIA 3; Ionotrophic Glutamate Receptor; ionotropic

• Clonality:

  Monoclonal, Recombinant

• Clone:

  A661

• Conjugation:

  Unconjugated

• Applications:

  WB

• Field of Research:

  Neuroscience; Signal Transduction

• Purification:

  Protein A purified

• Concentration:

  1 mg/mL

• Dilution:

  WB 1:1000

• Buffer:

  PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.

• Shipping Conditions:

  Ice bag

• Storage Conditions:

  Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

• Calculated Molecular Weight:

  101 kDa

• Observed Molecular Weight:

  101 kDa

• Isotype:

  IgG, κ