Recombinant beta III Tubulin Monoclonal Antibody

• Background:

  Beta III Tubulin (TUBB3) is one of six β-tubulin isoforms and is expressed highly during fetal and postnatal development (axon guidance and maturation) . Its expression levels decrease in the adult central nervous system (CNS) but remain high in the peripheral nervous system (PNS) . Microtubules enriched in β3-tubulin are more dynamic than those composed of other β-tubulin isoforms. Research studies have shown that mutations in the β3-tubulin gene TUBB3 cause ocular motility defects and other nervous system disorders. Furthermore, β3-tubulin is present in neoplastic but not in normal differentiated glial cells. Thus, β3-tubulin is a great neuronal marker.

• Abbreviation:

  Beta III Tubulin

• UniProt:

  Q13509

• Host:

  Rabbit

• Reactivity:

  Human; Rat; Mouse

• Immunogen:

  Recombinant human beta III Tubulin fragment

• Target:

  FEOM; beta; CFEOM; CDCBM; CDCBM1; CFEOM3; CFEOM3A; FEOM3; TUBB4; beta-4; beta Tubulin III; TUBB3; beta 3 tubulin; M (beta) 3; M (beta) 6; MC1R; Neuron specific beta III Tubulin; Neuron-specific class III beta-tubulin; QccE-11995; QccE-15186; TBB3; Tubb 3; Tubulin beta 3; Tubulin beta 3 chain; Tubulin beta 4; Tubulin beta III; Tubulin beta-3 chain; Tubulin beta-4 chain; Tubulin beta-III

• Clonality:

  Monoclonal, Recombinant

• Clone:

  A651

• Conjugation:

  Unconjugated

• Applications:

  WB; IHC

• Field of Research:

  Neuroscience; Signal Transduction; Tags & Cell Markers

• Purification:

  Protein A purified

• Concentration:

  1 mg/mL

• Dilution:

  WB 1:1000; IHC 1:200-1:1000

• Buffer:

  PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.

• Shipping Conditions:

  Ice bag

• Storage Conditions:

  Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

• Calculated Molecular Weight:

  50 kDa

• Observed Molecular Weight:

  50 kDa

• Isotype:

  IgG, κ