Recombinant SIGIRR Monoclonal Antibody

• Background:

  Acts as a negative regulator of the Toll-like and IL-1R receptor signaling pathways. Attenuates the recruitment of receptor-proximal signaling components to the TLR4 receptor, probably through an TIR-TIR domain interaction with TLR4. Through its extracellular domain interferes with the heterodimerization of Il1R1 and IL1RAP.

• Abbreviation:

  SIGIRR

• UniProt:

  Q9JLZ8

• Host:

  Rabbit

• Reactivity:

  Mouse

• Immunogen:

  Recombinant human SIGIRR fragment

• Target:

  Tir; Tir8; Sigirr

• Clonality:

  Monoclonal, Recombinant

• Clone:

  A360

• Conjugation:

  Unconjugated

• Applications:

  WB

• Purification:

  Protein A purified

• Concentration:

  1 mg/mL

• Dilution:

  WB 1:500-1:1000

• Buffer:

  PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.

• Shipping Conditions:

  Ice bag

• Storage Conditions:

  Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

• Calculated Molecular Weight:

  46 kDa

• Observed Molecular Weight:

  80 kDa

• Isotype:

  IgG, κ