Recombinant MSH2 Monoclonal Antibody

• Background:

  This locus is frequently mutated in hereditary nonpolyposis colon cancer (HNPCC) . When cloned, it was discovered to be a human homolog of the E. coli mismatch repair gene mutS, consistent with the characteristic alterations in microsatellite sequences (RER+ phenotype) found in HNPCC. Two transcript variants encoding different isoforms have been found for this gene.

• Abbreviation:

  MSH2

• UniProt:

  P43246

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  Recombinant human MSH2 fragment

• Target:

  FCC; MSH; COCA; LCFS; mutS homolog; MSH2; COCA1; FCC1; HNPCC; HNPCC1; LCFS2; mutS homolog 2; COCA1; FCC1; HNPCC; HNPCC1; LCFS2; mutS homolog 2; MSH2; COCA1; FCC1; HNPCC; HNPCC1; LCFS2

• Clonality:

  Monoclonal, Recombinant

• Clone:

  A307

• Conjugation:

  Unconjugated

• Applications:

  WB; IHC; IF; IP

• Field of Research:

  Epigenetics and Nuclear Signaling; Cancer

• Purification:

  Protein A purified

• Concentration:

  1 mg/mL

• Dilution:

  WB 1:500-1:1000; IHC 1:50; IF 1:50-1:100; IP 1:50-1:100

• Buffer:

  PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.

• Shipping Conditions:

  Ice bag

• Storage Conditions:

  Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

• Calculated Molecular Weight:

  105 kDa

• Observed Molecular Weight:

  104 kDa

• Isotype:

  IgG, κ