Recombinant CD33 Monoclonal Antibody

• Background:

  Sialic-acid-binding immunoglobulin-like lectin (Siglec) that plays a role in mediating cell-cell interactions and in maintaining immune cells in a resting state. Upon engagement of ligands such as C1q or syalylated glycoproteins, two immunoreceptor tyrosine-based inhibitory motifs (ITIMs) located in CD33 cytoplasmic tail are phosphorylated by Src-like kinases such as LCK. These phosphorylations provide docking sites for the recruitment and activation of protein-tyrosine phosphatases PTPN6/SHP-1 and PTPN11/SHP-2. In turn, these phosphatases regulate downstream pathways through dephosphorylation of signaling molecules.

• Abbreviation:

  CD33

• UniProt:

  P20138

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  Recombinant human CD33 fragment

• Target:

  CD33; SIGLEC-3; SIGLEC3; p67; CD33 molecule; gp67; Myeloid cell surface antigen CD33; Sialic acid-binding Ig-like lectin 3; Siglec-3; CD33 molecule; p67; SIGLEC3

• Clonality:

  Monoclonal, Recombinant

• Clone:

  A170

• Conjugation:

  Unconjugated

• Applications:

  IHC

• Field of Research:

  Immunology; Stem Cells

• Purification:

  Protein A purified

• Concentration:

  1 mg/mL

• Dilution:

  IHC 1:200-1:1000

• Buffer:

  PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.

• Shipping Conditions:

  Ice bag

• Storage Conditions:

  Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

• Isotype:

  IgG, κ