Recombinant Caldesmon/CDM Monoclonal Antibody

• Background:

  Actin- and myosin-binding protein implicated in the regulation of actomyosin interactions in smooth muscle and nonmuscle cells (could act as a bridge between myosin and actin filaments) . Stimulates actin binding of tropomyosin which increases the stabilization of actin filament structure. In muscle tissues, inhibits the actomyosin ATPase by binding to F-actin. This inhibition is attenuated by calcium-calmodulin and is potentiated by tropomyosin. Interacts with actin, myosin, two molecules of tropomyosin and with calmodulin. Also plays an essential role during cellular mitosis and receptor capping.

• Abbreviation:

  Caldesmon/CDM

• UniProt:

  Q05682

• Host:

  Rabbit

• Reactivity:

  Human; Rat; Mouse

• Immunogen:

  Recombinant human Caldesmon/CDM fragment

• Target:

  NAG; MGC; CALD1; CDM; H-CAD; HCAD; L-CAD; LCAD; NAG22; caldesmon; CALD 1; Caldesmon 1; Caldesmon 1 Isoform 1; Caldesmon 1 Isoform 2; Caldesmon 1 Isoform 3; Caldesmon 1 Isoform 4; Caldesmon 1 Isoform 5; Caldesmon1; H CAD; L CAD; MGC21352; CAD; CAD; CALD 1; CALD1; CALD1; Caldesmon 1; Caldesmon 1 Isoform 1; Caldesmon 1 Isoform 2; Caldesmon 1 Isoform 3; Caldesmon 1 Isoform 4; Caldesmon 1 Isoform 5; Caldesmon; Caldesmon1; CDM; H CAD; HCAD; L CAD; LCAD; MGC21352; NAG22

• Clonality:

  Monoclonal, Recombinant

• Clone:

  A147

• Conjugation:

  Unconjugated

• Applications:

  WB; IHC; IF

• Field of Research:

  Signal Transduction; Cardiovascular

• Purification:

  Protein A purified

• Concentration:

  1 mg/mL

• Dilution:

  WB 1:500-1:1000; IHC 1:200-1:1000; IF 1:50

• Buffer:

  PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.

• Shipping Conditions:

  Ice bag

• Storage Conditions:

  Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

• Calculated Molecular Weight:

  93 kDa

• Observed Molecular Weight:

  75 kDa

• Isotype:

  IgG, κ