D-Alanine

• Description :

  D-Alanine is a weak GlyR (inhibitory glycine receptor) and PMBA agonist, with an EC50 of 9 mM for GlyR[1][2].

• Product Name Alternative :

  (R) -Alanine; Ba 2776; D-α-Alanine

• UNSPSC :

  12352211

• Hazard Statement :

  H302, H315, H319, H335

• Target :

  Endogenous Metabolite

• Type :

  Natural Products

• Related Pathways :

  Metabolic Enzyme/Protease

• Applications :

  Metabolism-protein/nucleotide metabolism

• Field of Research :

  Neurological Disease

• Assay Protocol :

  https://www.medchemexpress.com/D-Alanine.html

• Purity :

  99.92

• Solubility :

  DMSO : < 1 mg/mL (ultrasonic; warming; heat to 80°C) |H2O : 120 mg/mL (ultrasonic)

• Smiles :

  N[C@@H](C(O)=O)C

• Molecular Formula :

  C3H7NO2

• Molecular Weight :

  89.09

• Precautions :

  H302, H315, H319, H335

• References & Citations :

  [1]Schmieden V, et al. Pharmacology of the inhibitory glycine receptor: agonist and antagonist actions of amino acids and piperidine carboxylic acid compounds. Mol Pharmacol. 1995 Nov;48 (5) :919-27.|[2]Saitoh T, et al. A novel antagonist, phenylbenzene omega-phosphono-alpha-amino acid, for strychnine-sensitive glycine receptors in the rat spinal cord. Br J Pharmacol. 1994 Sep;113 (1) :165-70.|[3]Mao Horio, et al. Effects of D-Amino Acid Oxidase Inhibitor on the Extracellular D-Alanine Levels and the Efficacy of D-Alanine on Dizocilpine-Induced Prepulse Inhibition Deficits in Mice. The Open Clinical Chemistry Journal, 2009, 2: 16-21

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Natural Products

• Clinical Information :

  No Development Reported

• Isoform :

  Human Endogenous Metabolite; Microbial Metabolite

• CAS Number :

  [338-69-2]