Recombinant Mucin 5AC Monoclonal Antibody

• Background:

  The cysteine residues in the Cys-rich subdomain repeats are not involved in disulfide bonding., Gel-forming glycoprotein of gastric and respiratoy tract epithelia that protects the mucosa from infection and chemical damage by binding to inhaled microrganisms and particules that are subsequently removed by the mucocilary system., PTM:C-, O- and N-glycosylated. O-glycosylated on the Thr-/Ser-rich tandem repeats. C-mannosylation in the Cys-rich subdomains may be required for proper folding of these regions and for export from the endoplasmic reticulum during biosynthesis., PTM:Proteolytic cleavage in the C-terminal is initiated early in the secretory pathway and does not involve a serine protease. The extent of cleavage is increased in the acidic parts of the secretory pathway. Cleavage generates a reactive group which could link the protein to a primary amide., similarity:Contains 1 CTCK (C-terminal cystine knot-like) domain., similarity:Contains 2 VWFC domains., similarity:Contains 4 VWFD domains., subunit:Multimeric. Interacts with H.pylori in the gastric epithelium, Barrett's esophagus as well as in gastric metaplasia of the duodenum (GMD) ., tissue specificity:Highly expressed in surface mucosal cells of respiratory tract and stomach epithelia. Overexpressed in a number of carcinomas. Also expressed in Barrett's esophagus epithelium and in the proximal duodenum.

• Abbreviation:

  Mucin 5AC

• UniProt:

  P98088

• Host:

  Rabbit

• Reactivity:

  Human; Mouse; Rat

• Immunogen:

  Recombinant Human Mucin 5AC protein

• Target:

  Gastric mucin|mucin; MUC; MUC5AC; MUC5; TBM; leB; mucin; mucin-5AC; MUC5A; Apomucin; Gastric mucin; gastric mucin|mucin 5; Major airway glycoprotein; MUC 5; Mucin 5 Subtypes A And C; Mucin 5AC; Mucin-5 subtype AC; subtypes A and C; tracheobronchial; tracheobronchial/gastric|mucin 5AC|tracheobronchial mucin; MUC-5AC; Mucin 5 Subtype AC; Tracheobronchial mucin; Apomucin Major Airway Glycoprotein; Lewis B blood group antigen; Mucin 5; Mucin 5 subtype AC tracheobronchial; Mucin 5 subtypes A and C tracheobronchial/gastric; Mucin 5AC oligomeric mucus/gel forming; oligomeric mucus/gel forming pseudogene; Tracheobronchial Mucin (TBM) ; tracheobronchial/gastric; MUC5AC

• Clonality:

  Monoclonal, Recombinant

• Clone:

  6C4

• Conjugation:

  Unconjugated

• Applications:

  WB; IHC

• Field of Research:

  Signal Transduction; Cancer

• Purification:

  Protein A

• Concentration:

  0.2 mg/mL

• Dilution:

  IHC 1:200-1:1000; WB 1:1000-1:5000

• Buffer:

  PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.

• Shipping Conditions:

  Ice bag

• Storage Conditions:

  Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

• Calculated Molecular Weight:

  586 kDa

• Observed Molecular Weight:

  586 kDa

• Isotype:

  IgG, κ