Recombinant Glucocorticoid Receptor Monoclonal Antibody

• Background:

  This gene encodes glucocorticoid receptor, which can function both as a transcription factor that binds to glucocorticoid response elements in the promoters of glucocorticoid responsive genes to activate their transcription, and as a regulator of other transcription factors. This receptor is typically found in the cytoplasm, but upon ligand binding, is transported into the nucleus. It is involved in inflammatory responses, cellular proliferation, and differentiation in target tissues. Mutations in this gene are associated with generalized glucocorticoid resistance. Alternative splicing of this gene results in transcript variants encoding either the same or different isoforms. Additional isoforms resulting from the use of alternate in-frame translation initiation sites have also been described, and shown to be functional, displaying diverse cytoplasm-to-nucleus trafficking patterns and distinct transcriptional activities (PMID:15866175) .

• Abbreviation:

  Glucocorticoid Receptor

• UniProt:

  P04150

• Host:

  Rabbit

• Reactivity:

  Human; Mouse; Rat

• Immunogen:

  Recombinant Human Glucocorticoid Receptor protein

• Target:

  NR3C; nuclear receptor subfamily; glucocorticoid nuclear receptor variant; Nuclear receptor subfamily 3 group C member; GCCR; GCR; GCRST; GR; GRL; NR3C1; glucocorticoid nuclear receptor variant 1; Glucocorticoid receptor; Grl1; group C; member 1 (glucocorticoid receptor) ; nuclear receptor subfamily 3; Nuclear receptor subfamily 3 group C member 1

• Clonality:

  Monoclonal, Recombinant

• Clone:

  12B8

• Conjugation:

  Unconjugated

• Applications:

  WB; IHC

• Field of Research:

  Epigenetics and Nuclear Signaling; Signal Transduction; Cancer

• Purification:

  Protein A

• Concentration:

  0.2 mg/mL

• Dilution:

  IHC 1:1000-1:4000; WB 1:1000-1:5000

• Buffer:

  PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.

• Shipping Conditions:

  Ice bag

• Storage Conditions:

  Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

• Calculated Molecular Weight:

  85 kDa

• Observed Molecular Weight:

  94 kDa

• Isotype:

  IgG, κ