Recombinant TROP-2/TACSTD2 Monoclonal Antibody

• Background:

  TROP-2, also referred to as tumor-associated calcium signal transducer 2 (TACSTD2), GA733-1 or M1S1, is a cell surface glycoprotein highly expressed in a wide variety of epithelial cancers. In contrast, there is little or no expression of Trop-2 in adult somatic tissue. Because it is a cell surface protein that is selectively expressed in tumor cells, Trop-2 is a potential therapeutic target. The cytoplasmic tail of Trop-2 possesses potential serine and tyrosine phosphorylation sites and a phosphatidyl-inositol binding consensus sequence. Trop-2 transduces an intracellular calcium signal, which are consistent with the hypothesis that it acts as a cell surface receptor and support a search for a physiological ligand. TROP2 encoding by an intronless gene was originally defined by the monoclonal antibody GA733, and is a member of a family of at least two type I membrane proteins. The other known member is GA733-2, also called EpCAM and TROP1. It has been suggested by studies that the GA733-1 gene was formed by the retroposition of the GA733-2 gene via an mRNA intermediate.

• Abbreviation:

  TACSTD2

• UniProt:

  Q8BGV3

• Host:

  Rabbit

• Reactivity:

  Mouse

• Immunogen:

  Recombinant Mouse TROP-2/TACSTD2 protein

• Target:

  EGP; Cell surface glycoprotein Trop; Tumor-associated calcium signal transducer; GA733; TACSTD; C80403; Cell surface glycoprotein Trop-2; EGP-1; GA733-1; Ly97; TROP-2; Tumor-associated calcium signal transducer 2; Trop2; Tacstd2

• Clonality:

  Monoclonal

• Clone:

  10A2

• Conjugation:

  Unconjugated

• Applications:

  IHC-P

• Purification:

  Protein A

• Concentration:

  1 mg/mL

• Dilution:

  IHC-P 1:10000-1:20000

• Buffer:

  0.2 μm filtered solution in PBS

• Shipping Conditions:

  Ice bag

• Storage Conditions:

  This antibody can be stored at 2°C-8°C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20°C to -80°C. Preservative-Free. Avoid repeated freeze-thaw cycles.

• Isotype:

  IgG