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DARS Monoclonal Antibody

CAT: 0763-AN200238PSize: 100 µLDry Ice: NoHazardous: No
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CAT#:0763-AN200238PSize:100 µL
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Background
This gene encodes a member of a multienzyme complex that functions in mediating the attachment of amino acids to their cognate tRNAs. The encoded protein ligates L-aspartate to tRNA (Asp) . Mutations in this gene have been found in patients showing hypomyelination with brainstem and spinal cord involvement and leg spasticity. Alternative splicing results in multiple transcript variants.
Abbreviation
DARS
UniProt
P14868
Host
Mouse
Reactivity
Human
Immunogen
Recombinant Human DARS Protein
Target
PIG; DARS; HBSL; aspRS; DARS1; PIG40
Clonality
Monoclonal
Clone
5H2
Conjugation
Unconjugated
Applications
IHC-P
Field of Research
Epigenetics and Nuclear Signaling
Purification
Protein A
Concentration
1 mg/mL
Dilution
IHC-P 1:30-1:100
Buffer
0.2 μm filtered solution in PBS
Shipping Conditions
Ice bag
Storage Conditions
This antibody can be stored at 2°C-8°C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20°C to -80°C. Preservative-Free. Avoid repeated freeze-thaw cycles.
Isotype
IgG1

UniProtKB · P14868

Aspartate--tRNA ligase, cytoplasmic

SYDC_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P14868
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
DARS1
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
6.1.1.12
Processing
—
Secondary accessions
A8K3J2, D3DP77, Q2TNI3, Q32Q69, Q53HV4, Q53YC5, Q68CR9, Q9BW52
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

PTM

AcetylationPhosphoprotein

Coding sequence diversity

Alternative splicing

Molecular function

Aminoacyl-tRNA synthetaseLigase

Ligand

ATP-bindingNucleotide-binding

Cellular component

Cytoplasm

Disease

Disease variant

Biological process

Protein biosynthesis

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