TSLP Recombinant Protein

• Background:

  TSLP is a hemopoietic protein that is expressed in the heart, liver and prostate. TSLP overlaps biological activities with IL-7 and binds with the heterodimeric receptor complex consisting of the IL-7R alpha chain (IL-7Rα ) and the TSLP-specific chain (TSLPR) . Like IL-7, TSLP induces phosphorylation of STAT3 and STAT5, but uses kinases other than the JAKs for activation. TSLP prohibited apoptosis and stimulated growth of the human acute myeloid leukemia (AML) -derived cell line MUTZ3. It induces the release of T cell-attracting chemokines TARC and MDC from monocytes and activates CD11c (+) dendritic cells (DCs) . TSLP activated DCs primed naïve T cells to produce the proallergic cytokines (IL-4, IL-5, IL-13, TNFα) while down-regulating IL-10 and IFN-γ suggesting a role in initiating allergic inflammation. Recombinant human TSLP is a 15.0 kDa protein consisting of 132 amino acid residues.

• NCBI Gene ID:

  85480

• Swiss Prot:

  Q969D9

• Accession Number:

  NP_149024.1

• Type:

  Recombinant Proteins

• Source:

  E. coli

• Field of Research:

  Chemokines & Cytokines, Immunology

• Shipping Conditions:

  Room Temp

• Storage Conditions:

  The lyophilized TSLP recombinant protein is stable for at least 2 years from date of receipt at -20˚ C. Reconstituted TSLP is stable for at least 3 months when stored in working aliquots with a carrier protein at -20˚ C. As with any protein, exposing TSLP recombinant protein to repeated freeze / thaw cycles is not recommended. When working with proteins care should be taken to keep recombinant protein at a cool and stable temperature.

• NCBI Official Name:

  Thymic stromal lymphopoietin

• NCBI Organism:

  Homo sapiens

• Other Product Names:

  Thymic stromal lymphopoietin

• Species:

  Human

• Protein ID:

  14719428

• Physical Properties:

  Lyophilized