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TSLP Recombinant Protein

CAT: 0223-40-294-01Size: 0.002 mgDry Ice: NoHazardous: No
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CAT#:0223-40-294-01Size:0.002 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
TSLP is a hemopoietic protein that is expressed in the heart, liver and prostate. TSLP overlaps biological activities with IL-7 and binds with the heterodimeric receptor complex consisting of the IL-7R alpha chain (IL-7Rα ) and the TSLP-specific chain (TSLPR) . Like IL-7, TSLP induces phosphorylation of STAT3 and STAT5, but uses kinases other than the JAKs for activation. TSLP prohibited apoptosis and stimulated growth of the human acute myeloid leukemia (AML) -derived cell line MUTZ3. It induces the release of T cell-attracting chemokines TARC and MDC from monocytes and activates CD11c (+) dendritic cells (DCs) . TSLP activated DCs primed naïve T cells to produce the proallergic cytokines (IL-4, IL-5, IL-13, TNFα) while down-regulating IL-10 and IFN-γ suggesting a role in initiating allergic inflammation. Recombinant human TSLP is a 15.0 kDa protein consisting of 132 amino acid residues.
NCBI Gene ID
85480
Swiss Prot
Q969D9
Accession Number
NP_149024.1
Type
Recombinant Proteins
Source
E. coli
Field of Research
Chemokines & Cytokines, Immunology
Shipping Conditions
Room Temp
Storage Conditions
The lyophilized TSLP recombinant protein is stable for at least 2 years from date of receipt at -20˚ C. Reconstituted TSLP is stable for at least 3 months when stored in working aliquots with a carrier protein at -20˚ C. As with any protein, exposing TSLP recombinant protein to repeated freeze / thaw cycles is not recommended. When working with proteins care should be taken to keep recombinant protein at a cool and stable temperature.
NCBI Official Name
Thymic stromal lymphopoietin
NCBI Organism
Homo sapiens
Other Product Names
Thymic stromal lymphopoietin
Species
Human
Protein ID
14719428
Physical Properties
Lyophilized

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