Oncostatin M Recombinant Protein

• Background:

  Oncostatin M (OSM) is a growth and differentiation factor that participates in the regulation of neurogenesis, osteogenesis and hematopoiesis. Produced by activate T cells, monocytes and Kaposi’s sarcoma cells, OSH can exert both stimulatory and inhibitory effects on cell proliferation. It stimulates the proliferation of fibroblasts, smooth muscle cells and Kaposi’s sarcoma cells, but, inhibits the growth of some normal and tumor cell lines. It also promotes cytokine release (e.g. IL-6, GM-CSF and G-CSF) from endothelial cells, and enhances the expression of low-density lipoprotein receptor in hepatoma cells. OSM share several structural and functional characteristics with LIF, IL-6, and CNTF. Human OSM is active on murine cells. The human OSM gene encodes for a 252 amino acid polypeptide, containing 25 amino acid signal sequence for secretion and a 227 precursor protein. Proteolytic processing of this precursor removes an 18 amino acid C-terminal peptide and generates the mature OSM form. Recombinant human Oncostatin M is a 23.9 kDa protein, containing 209 amino acid residues.

• NCBI Gene ID:

  5008

• Swiss Prot:

  P13725

• Accession Number:

  NP_065391.1

• Type:

  Recombinant Proteins

• Source:

  E. coli

• Field of Research:

  Chemokines & Cytokines, Immunology, Signal Transduction

• Shipping Conditions:

  Room Temp

• Storage Conditions:

  The lyophilized Oncostatin M recombinant protein is stable for at least 2 years from date of receipt at -20˚ C. Reconstituted Oncostatin M is stable for at least 3 months when stored in working aliquots with a carrier protein at -20˚ C. As with any protein, exposing Oncostatin M recombinant protein to repeated freeze / thaw cycles is not recommended. When working with proteins care should be taken to keep recombinant protein at a cool and stable temperature.

• NCBI Official Name:

  Oncostatin M

• NCBI Organism:

  Homo sapiens

• Other Product Names:

  Oncostatin-M, OSM

• Species:

  Human

• Protein ID:

  10092621

• Physical Properties:

  Lyophilized