SDLL-4 Recombinant Protein

• Background:

  Human sDLL4 comprises the extracellular signaling domain of DLL, a member of a structurally-related family of single-pass type I trans-membrane proteins that serve as ligands for Notch receptors. DLL4 functions to specifically activate the Notch-1 and Notch-4 receptors. The Notch signaling pathway regulates endothelial-cell differentiation, proliferation and apoptosis, and is essential for the development, maintenance and remodeling of the vascular system. Targeted deletion of the DLL4 gene in mice resulted in severe vascular defects and death before birth. Up-regulation of DLL4 expression has been implicated in the vascular development of certain tumors. Recombinant human sDLL4 is a 54.0 kDa glycoprotein containing 498 amino-acid residues.

• NCBI Gene ID:

  54567

• Swiss Prot:

  Q9NR61

• Accession Number:

  NP_061947.1

• Type:

  Recombinant Proteins

• Source:

  HEK293 cells

• Field of Research:

  Cancer, Chemokines & Cytokines, Immunology, Stem Cell

• Shipping Conditions:

  Room Temp

• Storage Conditions:

  The lyophilized sDLL-4 recombinant protein is stable for at least 2 years from date of receipt at -20˚ C. Reconstituted sDLL-4 is stable for at least 3 months when stored in working aliquots with a carrier protein at -20˚ C. As with any protein, exposing sDLL-4 recombinant protein to repeated freeze / thaw cycles is not recommended. When working with proteins care should be taken to keep recombinant protein at a cool and stable temperature.

• NCBI Official Name:

  Delta-like 4 (Drosophila)

• NCBI Organism:

  Homo sapiens

• Other Product Names:

  Hdelta2, Delta-like protein 4, Drosophila Delta homolog 4, Delta4

• Species:

  Human

• Protein ID:

  9506545

• Physical Properties:

  Lyophilized