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MIA Recombinant Protein

CAT: 0223-40-226-01Size: 0.005 mgDry Ice: NoHazardous: No
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CAT#:0223-40-226-01Size:0.005 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
MIA is the first discovered member of a family of secreted cytokines termed the MIA/OTOR family. The four known members of this family; MIA, MIA2, OTOR and TANGO each contain a Src homology-3 (SH3) -like domain. MIA is an autocrine growth regulatory protein secreted from chondrocytes and malignant melanoma cells that promotes melanoma metastasis by binding competitively to fibronectin and laminin in a manner that results in melanoma cell detachment from the extracellular matrix in vivo. Elevated levels of MIA may represent a clinically useful marker for diagnosis of melanoma metastasis as well as a potential marker for rheumatoid arthritis. Recombinant human MIA is a 12.2 kDa globular protein containing 108 amino acid residues including two intramolecular disulfide bonds.
NCBI Gene ID
8190
Swiss Prot
Q16674
Accession Number
NP_001189482.1
Type
Recombinant Proteins
Source
E. coli
Field of Research
Obesity
Shipping Conditions
Room Temp
Storage Conditions
The lyophilized MIA recombinant protein is stable for at least 2 years from date of receipt at -20˚ C. Reconstituted MIA is stable for at least 3 months when stored in working aliquots with a carrier protein at -20˚ C. As with any protein, exposing MIA recombinant protein to repeated freeze / thaw cycles is not recommended. When working with proteins care should be taken to keep recombinant protein at a cool and stable temperature.
NCBI Official Name
Melanoma inhibitory activity
NCBI Organism
Homo sapiens
Other Product Names
CD-RAP, Melanoma-derived growth regulatory protein, Melanoma inhibitory activity protein
Species
Human
Protein ID
321400133
Physical Properties
Lyophilized

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