Wnt-1 Recombinant Protein

• Background:

  Wnt-1 is a secreted protein that signals through the Frizzled family of cell surface receptors and is required for normal embryonic development. Wnt-1 activation induces a complex signaling cascade that ultimately leads to the increased expression of over fifty genes. An important component of Wnt-1 signaling is the stabilization, and resulting accumulation, of the intracellular signaling protein, beta-catenin. Wnt signaling induces and maintains the transformed phenotype and, in certain embryonic cell lines, supports self renewal in the absence of significant differentiation. Elevated levels of Wnt proteins are associated with tumorigenesis and are present in numerous human breast cancers. Mature human Wnt-1 is a glycosylated protein containing 343 amino acid residues. Recombinant human Wnt-1 is a 38.4 kDa, non-glycosylated protein containing 343 amino acid residues.

• NCBI Gene ID:

  7471

• Swiss Prot:

  P04628

• Accession Number:

  NP_005421.1

• Type:

  Recombinant Proteins

• Source:

  E. coli

• Field of Research:

  Cancer, Signal Transduction, Stem Cell

• Shipping Conditions:

  Room Temp

• Storage Conditions:

  The lyophilized Wnt-1 recombinant protein is stable for at least 2 years from date of receipt at -20˚ C. Reconstituted Wnt-1 is stable for at least 3 months when stored in working aliquots with a carrier protein at -20˚ C. As with any protein, exposing Wnt-1 recombinant protein to repeated freeze / thaw cycles is not recommended. When working with proteins care should be taken to keep recombinant protein at a cool and stable temperature.

• NCBI Official Name:

  Wingless-type MMTV integration site family, member 1

• NCBI Organism:

  Homo sapiens

• Other Product Names:

  INT1, OI15, BMND16, INT1, Proto-oncogene Wnt-1, Proto-oncogene Int-1 homolog

• Species:

  Human

• Protein ID:

  4885655

• Physical Properties:

  Lyophilized