MMP-1 Recombinant Protein

• Background:

  Matrix metalloproteinases (MMPs) are a family of endoproteases that require zinc and calcium for expressing catalytic activity. These enzymes play a central role in the maintenance and remodeling of the extracellular matrix. Elevated expression of their activity, caused either by up-regulation of their expression or down-regulation of their cognate inhibitors, has been implicated in various degenerative disorders, including arthritis, cardiovascular disease, skeletal growth-plate disorders, and cancer metastasis. MMP-1 is a secreted collagenase with specificity toward Type I, II, III, VII, and X collagens. Recombinant human MMP-1 is a 42.7 kDa protein containing the entire catalytic N-terminal domain and the C-terminal domain which is involved in substrate specificity and in binding TIMP-1.

• NCBI Gene ID:

  4312

• Swiss Prot:

  P03956

• Accession Number:

  NP_001139410.1

• Type:

  Recombinant Proteins

• Source:

  E. coli

• Field of Research:

  Cancer, Cell Cycle, Homeostasis, Neuroscience, Signal Transduction, Other

• Shipping Conditions:

  Room Temp

• Storage Conditions:

  The lyophilized MMP-1 recombinant protein is stable for at least 2 years from date of receipt at -20˚ C. Reconstituted MMP-1 is stable for at least 3 months when stored in working aliquots with a carrier protein at -20˚ C. As with any protein, exposing MMP-1 recombinant protein to repeated freeze / thaw cycles is not recommended. When working with proteins care should be taken to keep recombinant protein at a cool and stable temperature.

• NCBI Official Name:

  Matrix metallopeptidase 1 (interstitial collagenase)

• NCBI Organism:

  Homo sapiens

• Other Product Names:

  CLG, CLGN, CLG, Interstitial collagenase, Fibroblast collagenase, MMP-1

• Species:

  Human

• Protein ID:

  225543094

• Physical Properties:

  Lyophilized