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B7H3 Antibody [2A7]

CAT: 0223-RF16092-01Size: 0.02 mgDry Ice: NoHazardous: No
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CAT#:0223-RF16092-01Size:0.02 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
CD276, also known as B7-H3, was initially identified as a member of the B7 family of proteins through its homology with previously identified B7 molecules (1) . CD276 mRNA is widely expressed, but its protein expression is usually rather low (2) . CD276 has been shown to play a role in both the costimulation as well as the coinhibition of T cell response (3) . In a similar fashion, CD276 plays a critical role in the control of antitumor immune responses in some cases, while in others appears to mediate antitumor immunity (4) . It thus joins other immune checkpoint proteins as a possible therapeutic target for at least a subset of cancers.
NCBI Gene ID
80381
Swiss Prot
Q5ZPR3
Accession Number
NP_001019907
Host
Mouse
Reactivity
Human
Immunogen
B7-H3 antibody was raised against the extracellular domain of human B7-H3
Clonality
Monoclonal
Clone
2A7
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Immunology
Purification
B7-H3 Antibody is supplied as protein A purified IgG1.
Positive Control
Cat. No. 1210 - HEK293 Cell Lysate
Concentration
1 mg/mL
Buffer
B7-H3 Antibody is supplied in PBS containing 0.02% sodium azide and 50% glycerol.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
B7-H3 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Fragment
IgG1, k
Symbol
CD276
Positive Control 2
Cat. No. 17-010 - HEK293 Cell Slide
NCBI Official Name
CD276
NCBI Organism
Homo sapiens
Background Reference 01
Chapoval AI, Ni J, Lau JS, et al. B7-H3: a costimulatory molecule for T cell activation and IFN-gamma production. Nat Immunol 2001; 2:269-74.
Background Reference 02
Sun M, Richards S, Prasad DV, et al. Characterization of mouse and human B7-H3 genes. J Immunol 2002; 168:6294-7.
Background Reference 03
Yi KH and Chen L. Fine tuning the immune response through B7-H3 and B7-H4. Immunol Rev 2009; 229:145-51.
Background Reference 04
Wang L, Kang FB, and Shan BE. B7-H3-mediated tumor immunology: friend or foe?. Int J Cancer 2014; 134:2764-71.
Other Product Names
B7-H3 Antibody: CD276 molecule, B7H3, B7RP-2, 4Ig-B7-H3, CD276
Tested Applications
ELISA, WB, IHC-P, ICC, IF, Flow
Protein ID
67188443
Physical Properties
Liquid

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