PDL2 Antibody [4E10]

• Background:

  PD-L2 Antibody: Cell-mediated immune responses are initiated by T lymphocytes that are themselves stimulated by co gnate peptides bound to MHC molecules on antigen-presenting cells (APC) . T-cell activation is generally self-limited as activated T cells express receptors such as PD-1 (also known as PDCD-1) that mediate inhibitory signals from the APC. PD-1 can bind two different but related ligands, PD-L1 and PD-L2, both of which are thought act as a negative regulator of T cell activation. However, it has been suggested that PD-L2 can act to stimulate an immunogenic response through and alternative receptor from PD-1.

• NCBI Gene ID:

  80380

• Swiss Prot:

  P9BQ51

• Accession Number:

  NP_079515

• Host:

  Mouse

• Reactivity:

  Human

• Immunogen:

  PD-L2 antibody was raised against the extracellular domain of human PD-L2.

• Clonality:

  Monoclonal

• Clone:

  [4E10]

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Immunology

• Purification:

  PD-L2 Antibody is supplied as protein A purified IgG1.

• Positive Control:

  Cat. No. 1207 - Raji Cell Lysate

• Concentration:

  1 mg/mL

• Buffer:

  PD-L2 Antibody is supplied in PBS containing 0.02% sodium azide and 50% glycerol.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  PD-L2 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Fragment:

  IgG1

• Symbol:

  PDCD1LG2

• Positive Control 2:

  Cat. No. 1315 - Human Tonsil Tissue

• NCBI Official Name:

  Programmed cell death 1 ligand

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Holling TM, Schooten E, and van Den Elsing PJ. Function and regulation of MHC class II molecules in T-lymphocytes: of mice and men. Hum. Immunol. 2004; 65:282-90.

• Background Reference 02:

  Ishida Y, Agata Y, Shibahara K, et al. Induced expression of PD-1, a novel member of the immunoglobulin gene superfamily, upon programmed cell death. EMBO J. 1992; 11:3887-95.

• Background Reference 03:

  LaGier J and Pober JS. Immune accessory functions of human endothelial cells are modulated by overexpression of B7-H1 (PDL1) . Hum. Immunol. 2006; 67:568-78.

• Background Reference 04:

  Zhang Y, Chung Y, Bishop C, et al. Regulation of T cell activation and tolerance by PDL2. Proc. Natl. Acad. Sci. USA 2006; 103:11695-700.

• Other Product Names:

  PD-L2 Antibody: B7DC, Btdc, PDL2, CD273, PD-L2, PDCD1L2, bA574F11.2, B7DC, Programmed cell death 1 ligand 2, Butyrophilin B7-DC, PD-1 ligand 2

• Tested Applications:

  ELISA, WB, IHC-P, ICC, IF, Flow

• Protein ID:

  190014605

• Physical Properties:

  Liquid