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PDL2 Antibody [4E10]

CAT: 0223-RF16021-01Size: 0.02 mgDry Ice: NoHazardous: No
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CAT#:0223-RF16021-01Size:0.02 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
PD-L2 Antibody: Cell-mediated immune responses are initiated by T lymphocytes that are themselves stimulated by co gnate peptides bound to MHC molecules on antigen-presenting cells (APC) . T-cell activation is generally self-limited as activated T cells express receptors such as PD-1 (also known as PDCD-1) that mediate inhibitory signals from the APC. PD-1 can bind two different but related ligands, PD-L1 and PD-L2, both of which are thought act as a negative regulator of T cell activation. However, it has been suggested that PD-L2 can act to stimulate an immunogenic response through and alternative receptor from PD-1.
NCBI Gene ID
80380
Swiss Prot
P9BQ51
Accession Number
NP_079515
Host
Mouse
Reactivity
Human
Immunogen
PD-L2 antibody was raised against the extracellular domain of human PD-L2.
Clonality
Monoclonal
Clone
[4E10]
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Immunology
Purification
PD-L2 Antibody is supplied as protein A purified IgG1.
Positive Control
Cat. No. 1207 - Raji Cell Lysate
Concentration
1 mg/mL
Buffer
PD-L2 Antibody is supplied in PBS containing 0.02% sodium azide and 50% glycerol.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
PD-L2 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Fragment
IgG1
Symbol
PDCD1LG2
Positive Control 2
Cat. No. 1315 - Human Tonsil Tissue
NCBI Official Name
Programmed cell death 1 ligand
NCBI Organism
Homo sapiens
Background Reference 01
Holling TM, Schooten E, and van Den Elsing PJ. Function and regulation of MHC class II molecules in T-lymphocytes: of mice and men. Hum. Immunol. 2004; 65:282-90.
Background Reference 02
Ishida Y, Agata Y, Shibahara K, et al. Induced expression of PD-1, a novel member of the immunoglobulin gene superfamily, upon programmed cell death. EMBO J. 1992; 11:3887-95.
Background Reference 03
LaGier J and Pober JS. Immune accessory functions of human endothelial cells are modulated by overexpression of B7-H1 (PDL1) . Hum. Immunol. 2006; 67:568-78.
Background Reference 04
Zhang Y, Chung Y, Bishop C, et al. Regulation of T cell activation and tolerance by PDL2. Proc. Natl. Acad. Sci. USA 2006; 103:11695-700.
Other Product Names
PD-L2 Antibody: B7DC, Btdc, PDL2, CD273, PD-L2, PDCD1L2, bA574F11.2, B7DC, Programmed cell death 1 ligand 2, Butyrophilin B7-DC, PD-1 ligand 2
Tested Applications
ELISA, WB, IHC-P, ICC, IF, Flow
Protein ID
190014605
Physical Properties
Liquid

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