IRAK Antibody [8F1A7]

• Background:

  IRAK Monoclonal Antibody: Nuclear factor kappa B (NF-kappaB) is a ubiquitous transcription factor and an essential mediator of gene expression during activation of immune and inflammatory responses. NF-κ B mediates the expression of a great variety of genes in response to extracellular stimuli including IL-1, TNFalpha and LPS. A serine/threonine protein kinase associated with IL-1 receptor (IRAK) and its homologue mouse pelle-like protein kinase (mPLK) were identified recently. IRAK is associated with the IL-1 receptor subunits IL-1RI and IL-1RAcP after IL-1 binding and serves as a signaling molecule to mediate IL-1 response. IRAK mediates a signaling cascade leading to NF-κ B activation by members in IL-1 family including IL-1 and a novel cytokine IL-18 (also termed IGIF) .

• NCBI Gene ID:

  3654

• Swiss Prot:

  P51617

• Accession Number:

  P51617

• Host:

  Mouse

• Reactivity:

  Human, Mouse

• Immunogen:

  Recombinant protein corresponding to amino acids 618 - 712 of human IRAK.

• Clonality:

  Monoclonal

• Clone:

  8F1A7

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Signal Transduction, Innate Immunity

• Purification:

  IRAK Monoclonal Antibody is Protein G purified.

• Positive Control:

  Cat. No. 95-112 - IRAK Recombinant Protein

• Concentration:

  1 mg/mL

• Buffer:

  IRAK Monoclonal Antibody is supplied in PBS containing 0.02% sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  IRAK monoclonal antibody can be stored at -20˚ C, stable for one year.

• Fragment:

  IgG1

• Symbol:

  IRAK1

• NCBI Official Name:

  Interleukin-1 receptor-associated kinase 1

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Cao Z, ; Henzel WJ, and Gao X. IRAK: a kinase associated with the interleukin-1 receptor. Science 1996; 271:1128-31.

• Background Reference 02:

  Trofimova M, Sprenkle AB, Green M; et al. Developmental and tissue-specific expression of mouse pelle-like protein kinase. J. Bio. Chem. 1996; 271: 17609-12.

• Background Reference 03:

  Jianing Huang, Xiong Gao, Shyun Li, et al. Recruitment of IRAK to the interleukin 1 receptor complex requires interleukin-1 receptor accessory protein. Proc. Natl. Acad. Sci. USA 1997; 94:12829-32.

• Background Reference 04:

  Robinson D, Shibuya K, Mui A, et al. IGIF does not drive Th1 development but synergizes with IL-12 for interferon-gamma production and activates IRAK and NF-kB. Immunity 1997; 7:571-81.

• Other Product Names:

  IRAK Antibody [8F1A7] : IRAK, pelle

• Tested Applications:

  ELISA, WB, IHC-P

• Protein ID:

  8928535

• Physical Properties:

  Liquid