ORAI1 Antibody [6D11A11]

• Background:

  ORAI1 Monoclonal Antibody: Antigen stimulation of immune cells triggers Ca++ entry through Ca++ release-activated Ca++ (CRAC) channels. ORAI1 is a recently identified four-transmembrane spanning protein that is an essential component of CRAC. A missense mutation in this protein in humans is the cause of one form of hereditary severe combined immune deficiency (SCID) which results in ablated T-cell Ca++ entry. It has been suggested that ORAI1 functions as a highly selective Ca++ plasma membrane channel that is gated through interactions with STIM1, the store-activated endoplasmic reticulum Ca++ sensor.

• NCBI Gene ID:

  84876

• Swiss Prot:

  Q96D31

• Accession Number:

  Q96D31

• Host:

  Mouse

• Reactivity:

  Human, Mouse, Rat

• Immunogen:

  Mouse monoclonal ORAI1 antibody was raised against a 16 amino acid synthetic peptide from near the carboxy terminus of human ORAI1.

• Clonality:

  Monoclonal

• Clone:

  6D11A11

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Immunology

• Purification:

  ORAI1 Monoclonal Antibody is Protein A purified.

• Positive Control:

  Cat. No. 1366 - Human Spleen Tissue Lysate

• Concentration:

  1 mg/mL

• Buffer:

  ORAI1 Monoclonal Antibody is supplied in PBS containing 0.02% sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  ORAI1 monoclonal antibody can be stored at -20˚ C, stable for one year.

• Fragment:

  IgG2b

• Specificity:

  ORAI1 antibody is predicted to have no cross-reactivity to ORAI2 or ORAI3.

• Symbol:

  ORAI1

• Positive Control 2:

  Cat. No. 10-901 - Human Spleen Tissue Slide

• NCBI Official Name:

  ORAI calcium release-activated calcium modulator 1

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Lewis RS. Calcium signaling mechanisms in T lymphocytes. Annu. Rev. Immunol. 2001; 19:497-521.

• Background Reference 02:

  Feske S, Gwack Y, Prakriya M, et al. A mutation in Orai1 causes immune deficiency by abrogating CRAC channel function. Nature 2006; 441:179-85.

• Background Reference 03:

  Soboloff J, Spassova MA, Dziadek MA, et al. Calcium signals mediated by STIM and Orai proteins - a new paradigm in inter-organelle communication. Biochim. Biophys. Acta. 2006; 1763:1161-8.

• Other Product Names:

  ORAI1 Antibody [6D11A11] : IMD9, ORAT1, CRACM1, TMEM142A

• Tested Applications:

  ELISA, WB, IHC-P, IF

• Protein ID:

  97180269

• Physical Properties:

  Liquid