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CD71 Antibody [RI7217]

CAT: 0223-98-839Size: 0.5 mgDry Ice: YesHazardous: No
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CAT#:0223-98-839Size:0.5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
CD71, a type II transmembrane glycoprotein expressed on the cell surface as a homodimer, is the transferrin receptor. It is essential for the growth of normal and neoplastic cells. It is expressed at low levels on resting B and T lymphocytes but is upregulated during responses to antigens and mitogens presumably reflecting the iron dependence of proliferation. Its expression declines with maturation and differentiation. CD71 plays a critical role in cell proliferation by controlling the supply of iron which is essential for many metabolic pathways through the binding and endocytosis of transferrin, the major iron-carrying protein. It may also be involved in signal transduction via its association with the T cell receptor ζ chain. The monoclonal antibody RI7217 inhibits cell proliferation in vitro.
NCBI Gene ID
22042
Swiss Prot
Q62351
Accession Number
Q62351
Host
Rat
Reactivity
Mouse
Immunogen
DMSO induced Friend erythroleukemia 745.6
Clonality
Monoclonal
Clone
[RI7217]
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Immunology, Obesity, Signal Transduction
Concentration
0.5 mg/mL
Buffer
Supplied in PBS
Modification
None
Shipping Conditions
Dry Ice
Storage Conditions
Store vial at -20˚ C
Fragment
IgG2a
Specificity
CD71
Applications Notes
CD71 Antibody [RI7217] for use in flow cytometry, immunocytochemistry, western blotting, immunoprecipitation, blocking, separation, and drug delivery assays.
Symbol
Tfrc
NCBI Official Name
Transferrin receptor
NCBI Organism
Mus musculus
Other Product Names
T9, transferrin receptor, TfR
Tested Applications
WB, IHC-Fr, ICC, Flow, IP
Physical Properties
Liquid

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