CD71 Antibody [RI7217]

• Background:

  CD71, a type II transmembrane glycoprotein expressed on the cell surface as a homodimer, is the transferrin receptor. It is essential for the growth of normal and neoplastic cells. It is expressed at low levels on resting B and T lymphocytes but is upregulated during responses to antigens and mitogens presumably reflecting the iron dependence of proliferation. Its expression declines with maturation and differentiation. CD71 plays a critical role in cell proliferation by controlling the supply of iron which is essential for many metabolic pathways through the binding and endocytosis of transferrin, the major iron-carrying protein. It may also be involved in signal transduction via its association with the T cell receptor ζ chain. The monoclonal antibody RI7217 inhibits cell proliferation in vitro.

• NCBI Gene ID:

  22042

• Swiss Prot:

  Q62351

• Accession Number:

  Q62351

• Host:

  Rat

• Reactivity:

  Mouse

• Immunogen:

  DMSO induced Friend erythroleukemia 745.6

• Clonality:

  Monoclonal

• Clone:

  [RI7217]

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cancer, Immunology, Obesity, Signal Transduction

• Concentration:

  0.5 mg/mL

• Buffer:

  Supplied in PBS

• Modification:

  None

• Shipping Conditions:

  Dry Ice

• Storage Conditions:

  Store vial at -20˚ C

• Fragment:

  IgG2a

• Specificity:

  CD71

• Applications Notes:

  CD71 Antibody [RI7217] for use in flow cytometry, immunocytochemistry, western blotting, immunoprecipitation, blocking, separation, and drug delivery assays.

• Symbol:

  Tfrc

• NCBI Official Name:

  Transferrin receptor

• NCBI Organism:

  Mus musculus

• Other Product Names:

  T9, transferrin receptor, TfR

• Tested Applications:

  WB, IHC-Fr, ICC, Flow, IP

• Physical Properties:

  Liquid