CD23 Antibody [2G8] (APC)

• Background:

  The CD23 antigen is the low affinity IgE Fc receptor, which is a 45-49 kDa protein with 38 and 28 kDa fragments. It is expressed on most mature, conventional B cells (but not on peritoneal CD5+ B cells) and can also be found on the surface of T cells, macrophages and platelets. It is distinct from the high affinity IgE receptors found on basophils and mast cells which mediate allergic reactions. The low affinity receptors are thought to play a role in isotype specific immunoregulation. The regulation of CD23 surface expression appears to be integral with the complex IgE system which involves interactions of cells, cytokines, antibodies and regulatory factors. CD23 has been described as a “membrane bound cytokine, " in that the soluble cleavage products of CD23 are themselves able to act as cytokines in vitro.

• NCBI Gene ID:

  14128

• Swiss Prot:

  P20693

• Accession Number:

  P20693

• Host:

  Rat

• Reactivity:

  Mouse

• Immunogen:

  FcepsilonR isolated from B cell lymphoma cell line M12.4.5

• Clonality:

  Monoclonal

• Clone:

  [2G8]

• Conjugation:

  APC

• Type:

  Primary Antibodies

• Field of Research:

  Immunology, Stem Cell, Cancer, Cell Cycle

• Concentration:

  0.1 mg/mL

• Buffer:

  Supplied in PBS/NaN3 and a stabilizing agent

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store vial at 2-8˚ C

• Fragment:

  IgG2a

• Specificity:

  CD23

• Applications Notes:

  CD23 Antibody [2G8] for use in flow cytometry assays.

• Symbol:

  Fcer2a

• NCBI Official Name:

  Fc receptor, IgE, low affinity II, alpha polypeptide

• NCBI Organism:

  Mus musculus

• Other Product Names:

  FcepsilonRII, BLAST-2, low affinity IgE receptor, Ly-42

• Tested Applications:

  IHC-P, IHC-Fr, ICC, Flow, IP

• Physical Properties:

  Liquid