IGF1R (phospho Tyr1346) Antibody

• Background:

  This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival.

• NCBI Gene ID:

  3480

• Swiss Prot:

  P08069

• Accession Number:

  NP_000866.1

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Immunogen:

  IGF1R (phospho Tyr1346) antibody was raised against a peptide sequence around phosphorylation site of tyrosine 1346 (Q-P-Y (p) -A-H) derived from Human IGF1R .

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Phospho-Specific

• Purification:

  Antibodies were purified by affinity-chromatography using epitope-specific peptide.

• Concentration:

  1 mg/mL

• Buffer:

  Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

• Modification:

  Phospho-Specific

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store antibody at -20˚ C for up to one year.

• Calculated Molecular Weight:

  154 kDa

• Fragment:

  IgG

• Specificity:

  The antibody detects endogenous levels of IGF1R only when phosphorylated at tyrosine 1346.

• Symbol:

  IGF1R

• NCBI Official Name:

  Insulin-like growth factor 1 receptor

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Ullrich A., EMBO J. 5:2503-2512 (1986) .

• Background Reference 02:

  Abbot A.M., J. Biol. Chem. 267:10759-10763 (1992) .

• Background Reference 03:

  The MGC Project Team; Genome Res. 14:2121-2127 (2004) .

• Other Product Names:

  CD221, kinase IGF1R, IGF1R

• Tested Applications:

  IHC

• Protein ID:

  4557665

• Physical Properties:

  Liquid