SCF Antibody

CAT: 0223-79-769Size: 0.1 mgDry Ice: NoHazardous: No
CAT#:0223-79-769Size:0.1 mg
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Background
Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. KITLG/SCF binding can activate several signaling pathways. Promotes phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, and subsequent activation of the kinase AKT1. KITLG/SCF and KIT also transmit signals via GRB2 and activation of RAS, RAF1 and the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. KITLG/SCF and KIT promote activation of STAT family members STAT1, STAT3 and STAT5. KITLG/SCF and KIT promote activation of PLCG1, leading to the production of the cellular signaling molecules diacylglycerol and inositol-1, 4, 5-trisphosphate. KITLG/SCF acts synergistically with other cytokines, probably interleukins.
NCBI Gene ID
4254
Swiss Prot
P21583
Accession Number
NP_000890.1
Host
Rabbit
Reactivity
Human
Immunogen
SCF antibody was raised against a peptide sequence around aa.265~269 (E-K-E-R-E) derived from Human SCF.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Stem Cell
Purification
Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Concentration
1 mg/mL
Buffer
Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store antibody at -20˚ C for up to one year.
Calculated Molecular Weight
25 - 38 kDa
Specificity
This antibody detects endogenous level of total SCF protein.
Applications Notes
Western Blot: 1:500~1:1000
Symbol
KITLG
NCBI Official Name
KIT ligand
NCBI Organism
Homo sapiens
Background Reference 01
Lu H. S., Clogston C. L., Wypych J., Parker V. P., Lee T. D., Swiderek K., Baltera R. F. Jr., Patel A. C., Chang D. C., Brankow D. W., Liu X. -D., Ogden S. G., Karkare S. B., Hu S. S., Zsebo K. M., Langley K. E. Arch. Biochem. Biophys. 298:150-158 (1992)
Other Product Names
SF, MGF, SCF, FPH2, KL-1, Kitl, SHEP7, BCR1, D22S11, SF
Tested Applications
WB
Protein ID
4505175
Physical Properties
Liquid

Related Products

CatalogName
5165PSCF Peptide
90-537SCF Recombinant Protein
40-438-0002mgSCF Recombinant Protein
90-538SCF Recombinant Protein
90-541SCF Recombinant Protein
91-924SCF Recombinant Protein
91-025SCF Recombinant Protein
90-539SCF Recombinant Protein
40-474-001mgSCF Recombinant Protein
40-282-0002mgSCF Recombinant Protein

Alternative Products

CatalogName
MBS850197-01Antibody to IGFBP2 Antibody
MBS8529199-01H2B Antibody Antibody
DF8746-01ASAP1 antibody Antibody
MBS8513599-01CD11b Antibody Antibody
E8M1007-4HSP60 Antibody Antibody
GWB-250026Lck antibody Antibody
E36403ZNF98 Antibody Antibody
MBS9403836-01SZT2 Antibody Antibody
LSMab09882anti-Antibody^Polyclonal antibody control antibody
AN100003PPAK1 Antibody Polyclonal Antibody

Popular Products