ABCG2 (CD338) Antibody

• Background:

  Xenobiotic transporter that may play an important role in the exclusion of xenobiotics from the brain. May be involved in brain-to-blood efflux. Appears to play a major role in the multidrug resistance phenotype of several cancer cell lines. When overexpressed, the transfected cells become resistant to mitoxantrone, daunorubicin and doxorubicin, display diminished intracellular accumulation of daunorubicin, and manifest an ATP-dependent increase in the efflux of rhodamine 123.

• NCBI Gene ID:

  9429

• Swiss Prot:

  Q9UNQ0

• Accession Number:

  NP_004818.2

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Immunogen:

  ABCG2 (CD338) antibody was raised against a peptide sequence around aa.160~164 (R-I-N-R-V) derived from Human ABCG2 (CD338) .

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Stem Cell

• Purification:

  Antibodies were purified by affinity-chromatography using epitope-specific peptide.

• Concentration:

  1 mg/mL

• Buffer:

  Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store antibody at -20˚ C for up to one year.

• Calculated Molecular Weight:

  65 - 80 kDa

• Specificity:

  This antibody detects endogenous level of total ABCG2 (CD338) protein.

• Applications Notes:

  Western Blot: 1:500

• Symbol:

  ABCG2

• NCBI Official Name:

  ATP-binding cassette, sub-family G (WHITE), member 2

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Henriksen U., Gether U., Litman T. J. Cell Sci. 118:1417-1426 (2005) Wakabayashi K., Nakagawa H., Tamura A., Koshiba S., Hoshijima K., Komada M., Ishikawa T. J. Biol. Chem. 282:27841-27846 (2007)

• Other Product Names:

  MRX, MXR, ABCP, BCRP, BMDP, MXR1, ABC15, BCRP1, CD338, GOUT1, CDw338, UAQTL1, EST157481, MRX

• Tested Applications:

  WB

• Protein ID:

  62526033

• Physical Properties:

  Liquid