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Caspase 3 Antibody

CAT: 0223-79-641Size: 0.1 mgDry Ice: NoHazardous: No
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CAT#:0223-79-641Size:0.1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly (ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin.
NCBI Gene ID
836
Swiss Prot
P42574
Accession Number
NP_004337.2
Host
Rabbit
Reactivity
Human
Immunogen
Caspase 3 antibody was raised against a peptide sequence around aa.29~33 (S-G-I-S-L) derived from Caspase 3.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Apoptosis, Cancer
Purification
Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Concentration
1 mg/mL
Buffer
Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store antibody at -20˚ C for up to one year.
Calculated Molecular Weight
35 19 17 kDa
Specificity
This antibody detects endogenous level of total Caspase 3 protein.
Applications Notes
Western Blot: 1:1000
Symbol
CASP3
NCBI Official Name
Caspase 3, apoptosis-related cysteine peptidase
NCBI Organism
This antibody was raised against a peptide sequence around aa.29~33 (S-G-I-S-L) derived from Caspase 3.
Background Reference 01
Gervais, F. G et al. Cell 97: 395-406, 1999. Nicholson, D. W. et al. (1995) Nature 376, 37-43.
Other Product Names
CPP32, SCA-1, CPP32B, SCFR, Apopain
Tested Applications
WB
Protein ID
14790119
Physical Properties
Liquid

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