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P73 (Ab 99) Antibody

CAT: 0223-79-527Size: 0.1 mgDry Ice: NoHazardous: No
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CAT#:0223-79-527Size:0.1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
This gene encodes tumor protein p73, which is a member of the p53 family of transcription factors involved in cellular responses to stress and development. The family members include p53, p63, and p73 and have high sequence similarity to one another, which allows p63 and p73 to transactivate p53-responsive genes causing cell cycle arrest and apoptosis. The family members can interact with each other in many ways involving direct or indirect protein interactions, resulting in regulation of the same target gene promoters or regulation of each other's promoters. The p73 protein is expressed at very low levels in normal tissues and is differentially expressed in a number of tumors. The p73 gene expresses at least 35 mRNA variants due to the use of alternate promoters, alternate translation initiation sites, and multiple splice variations. Theoretically this can account for 29 different p73 isoforms; however, the biological validity and the full-length nature of most variants have not been determined.
NCBI Gene ID
7161
Swiss Prot
O15350
Accession Number
NP_001119712.1
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
P73 (Ab-99) antibody was raised against a peptide sequence around aa.97~101 (S-P-Y-A-Q) derived from Human P73.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Apoptosis, Cancer, Cell Cycle
Purification
Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Concentration
1 mg/mL
Buffer
Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store antibody at -20˚ C for up to one year.
Calculated Molecular Weight
80 kDa
Specificity
This antibody detects endogenous level of total p73 protein.
Applications Notes
Western Blot: 1:500~1:1000
Symbol
TP73
NCBI Official Name
Tumor protein p73
NCBI Organism
Homo sapiens
Background Reference 01
Yuan ZM, et al. (1999) Nature. 399 (6738) : 814-817.
Other Product Names
P73, TP73, TRP73, p53-related protein, p73-alpha
Tested Applications
WB
Protein ID
187828902
Physical Properties
Liquid

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