CD279 Antibody [MIH4] (FITC)

• Background:

  The MIH4 monoclonal antibody specifically reacts with human Programmed death-1 (PD-1 or CD279), a 50-55 kDA glycoprotein. It is expressed on mainly on activated B, T, and myeloid cells. Within the cytoplasmic region, PD-1 contains an Immunoreceptor tyrosine-based inhibitory motif (ITIM) and seems to regulate peripheral tolerance. The lack or mutation of CD279 is linked to autoimmune disorders.

• NCBI Gene ID:

  5133

• Swiss Prot:

  Q15116

• Host:

  Mouse

• Reactivity:

  Human

• Clonality:

  Monoclonal

• Clone:

  MIH4

• Conjugation:

  FITC

• Type:

  Primary Antibodies

• Field of Research:

  Immunology, Apoptosis

• Purification:

  The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.

• Concentration:

  Batch dependent

• Buffer:

  Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  The product should be stored undiluted at 4˚ C and should be protected from prolonged exposure to light. Do not freeze.

• Fragment:

  Mouse IgG1, kappa

• Specificity:

  The MIH4 monoclonal antibody specifically reacts with human Programmed death-1 (PD-1 or CD279), a 50-55 kDA glycoprotein.

• Symbol:

  PDCD1

• NCBI Official Name:

  Programmed cell death 1

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Nishimura, H., Agata, Y., Kawasaki, A., Sato, M., Imamura, S., Minato, N., ... Honjo, T. (1996) . Developmentally regulated expression of the PD-1 protein on the surface of double-negative (CD4CD8) thymocytes.International immunology,8 (5), 773-780.

• Background Reference 02:

  Salama, A. D., Chitnis, T., Imitola, J., Ansari, M. J. I., Akiba, H., Tushima, F., ... Khoury, S. J. (2003) . Critical role of the programmed death-1 (PD-1) pathway in regulation of experimental autoimmune encephalomyelitis.The Journal of experimental medicine,198 (1), 71-78.

• Background Reference 03:

  Carreno, B. M., Collins, M. (2002) . The B7 family of ligands and its receptors: new pathways for costimulation and inhibition of immune responses.Annual review of immunology,20 (1), 29-53.

• Other Product Names:

  PD1, PD-1, CD279, SLEB2, hPD-1, hPD-l, hSLE1, PDCD1

• Tested Applications:

  Flow

• Physical Properties:

  Liquid