CD282 Antibody [TL2.1] (FITC)

• Background:

  The TL2.1 monoclonal antibody specifically reacts with human CD282, the Toll-like receptor 2 (TLR2) . It is a type I transmembrane signaling receptor containing IL-1 receptor like intracellular domain and leucine-rich repeats (LRR) in the extracellular domain. CD282 is expressed on peripheral blood monocytes and is involved distinguishing bacterial lipoproteins. The TL2.1 antibody blocks the receptor and immunoprecipitates TLR2 from human mammary epithelial cells (HMEC) and peripheral blood mononuclear cells (PBMC) .

• NCBI Gene ID:

  7097

• Swiss Prot:

  O60603

• Host:

  Mouse

• Reactivity:

  Human

• Clonality:

  Monoclonal

• Clone:

  TL2.1

• Conjugation:

  FITC

• Type:

  Primary Antibodies

• Field of Research:

  Innate Immunity

• Purification:

  The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.

• Concentration:

  Batch dependent

• Buffer:

  Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  The product should be stored undiluted at 4˚ C and should be protected from prolonged exposure to light. Do not freeze.

• Fragment:

  Mouse IgG2a, kappa

• Specificity:

  The TL2.1 monoclonal antibody specifically reacts with human CD282, the Toll-like receptor 2 (TLR2) .

• Symbol:

  TLR2

• NCBI Official Name:

  Toll-like receptor 2

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Flo, T. H., Halaas, ., Lien, E., Ryan, L., Teti, G., Golenbock, D. T., ... Espevik, T. (2000) . Human toll-like receptor 2 mediates monocyte activation by Listeria monocytogenes, but not by group B streptococci or lipopolysaccharide.The Journal of Immunology,164 (4), 2064-2069.

• Background Reference 02:

  Lien, E., Sellati, T. J., Yoshimura, A., Flo, T. H., Rawadi, G., Finberg, R. W., ... Golenbock, D. T. (1999) . Toll-like receptor 2 functions as a pattern recognition receptor for diverse bacterial products.Journal of Biological Chemistry,274 (47), 33419-33425.

• Background Reference 03:

  Cook, E. B., Stahl, J. L., Esnault, S., Barney, N. P., Graziano, F. M. (2005) . Toll-like receptor 2 expression on human conjunctival epithelial cells: a pathway for

• Other Product Names:

  TIL4, CD282, TLR2

• Tested Applications:

  Flow

• Physical Properties:

  Liquid