CD127 Antibody [A7R34] (FITC)

• Background:

  The A7R34 monoclonal antibody specifically reacts with the mouse CD127, the alpha subunit of the IL-7 receptor, expressed by immature B lymphocytes in the bone marrow, CD4-/CD8-, CD4+, and CD8+ thymocytes, and by mature T lymphocytes at low levels. Mature T cells express CD117 at low levels in the periphery.The A7R34 antibody prevents the interaction between IL-7 and its receptor and the binding of mAb SB/199, which also recognizes mouse CD127.

• NCBI Gene ID:

  16197

• Swiss Prot:

  P16872

• Host:

  Rat

• Reactivity:

  Mouse

• Clonality:

  Monoclonal

• Clone:

  A7R34

• Conjugation:

  FITC

• Type:

  Primary Antibodies

• Field of Research:

  Immunology

• Purification:

  The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.

• Concentration:

  Batch dependent

• Buffer:

  Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  The product should be stored undiluted at 4˚ C and should be protected from prolonged exposure to light. Do not freeze.

• Fragment:

  Rat IgG2a, kappa

• Specificity:

  The A7R34 monoclonal antibody specifically reacts with the mouse CD127, the alpha subunit of the IL-7 receptor, expressed by immature B lymphocytes in the bone marrow, CD4-/CD8-, CD4+, and CD8+ thymocytes, and by mature T lymphocytes at low levels.

• Symbol:

  Il7r

• NCBI Official Name:

  Interleukin 7 receptor

• NCBI Organism:

  Mus musculus

• Background Reference 01:

  Sudo, T., Nishikawa, S. A. T. O. M. I., Ohno, N. O. R. I. K. O., Akiyama, N. A. O. K. O., Tamakoshi, M. A. S. A. T. A. D. A., Yoshida, H. I. S. A. H. I. R. O. (1993) . Expression and function of the interleukin 7 receptor in murine lymphocytes.Proceedings of the National Academy of Sciences,90 (19), 9125-9129.

• Background Reference 02:

  Hashi, H., Yoshida, H., Honda, K., Fraser, S., Kubo, H., Awane, M., ... Nishikawa, S. I. (2001) . Compartmentalization of Peyers patch anlagen before lymphocyte entry.The Journal of Immunology,166 (6), 3702-3709.

• Background Reference 03:

  Okuno, Y., Iwasaki, H., Huettner, C. S., Radomska, H. S., Gonzalez, D. A., Tenen, D. G., Akashi, K. (2002) . Differential regulation of the human and murine CD34 genes in hematopoietic stem cells.Proceedings of the National Academy of Sciences,99 (9), 6246-6251.

• Other Product Names:

  CD127, IL-7Ralpha, Il7r

• Tested Applications:

  Flow

• Physical Properties:

  Liquid