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CD152 Antibody [BNI3] (APC)

CAT: 0223-76-848Size: 25 TestsDry Ice: NoHazardous: No
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CAT#:0223-76-848Size:25 Tests
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
The BNI3 monoclonal antibody specifically reacts with human CD152, the Cytotoxic T-Lymphocyte Antigen 4 (CTLA-4) . CTLA-4 is expressed on activated CD28+ T cells, and binds the B7 family members B7-1 (CD80) and B7-2 (CD86) . The structure of CTLA-4 is similar to the structure of CD28, but the two molecules seem to have opposite roles on the T lymphocytes. CTLA-4 inhibits the progression of T cell activation, while CD28 stimulates it. This result explains the stimulating role that the immobilization of BNI3 plays on the T lymphocytes proliferation induced by CD28.
NCBI Gene ID
1493
Swiss Prot
P16410
Host
Mouse
Reactivity
Human
Clonality
Monoclonal
Clone
BNI3
Conjugation
APC
Type
Primary Antibodies
Field of Research
Immunology
Purification
The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.
Concentration
Batch dependent
Buffer
Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
The product should be stored undiluted at 4˚ C and should be protected from prolonged exposure to light. Do not freeze.
Fragment
Mouse IgG2a, kappa
Specificity
The BNI3 monoclonal antibody specifically reacts with human CD152, the Cytotoxic T-Lymphocyte Antigen 4 (CTLA-4) .
Symbol
CTLA4
NCBI Official Name
Cytotoxic T-lymphocyte-associated protein 4
NCBI Organism
Homo sapiens
Background Reference 01
Alegre, M. L., Noel, P. J., Eisfelder, B. J., Chuang, E., Clark, M. R., Reiner, S. L., Thompson, C. B. (1996) . Regulation of surface and intracellular expression of CTLA4 on mouse T cells.The Journal of Immunology,157 (11), 4762-4770.
Background Reference 02
Walunas, T. L., Lenschow, D. J., Bakker, C. Y., Linsley, P. S., Freeman, G. J., Green, J. M., ... Bluestone, J. A. (1994) . CTLA-4 can function as a negative regulator of T cell activation.Immunity,1 (5), 405-413.
Background Reference 03
Cilio, C. M., Daws, M. R., Malashicheva, A., Sentman, C. L., Holmberg, D. (1998) . Cytotoxic T Lymphocyte Antigen 4 Is Induced in the Thymus upon In Vivo Activation and Its Blockade Prevents Anti-CD3mediated Depletion of Thymocytes.The Journal of experimental medicine,188 (7), 1239-1246.
Other Product Names
CD, GSE, GRD4, ALPS5, CD152, CTLA-4, IDDM12, CELIAC3, CTLA4
Tested Applications
Flow
Physical Properties
Liquid

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