CD27 Antibody [O323] (APC-Cy7)

• Background:

  The O323 monoclonal antibody specifically binds to the human CD27, which is a lymphocyte-specific member of the TNF/NGF-R family, expressed on a subset of human thymocytes and the majority of the mature T cells. CD27 is upregulated by T lymphocytes stimulation, and binds to CD70, enhancing the interaction between T and B lymphocytes. CD27 is a marker of memory B cells.

• NCBI Gene ID:

  939

• Swiss Prot:

  P26842

• Host:

  Mouse

• Reactivity:

  Human

• Clonality:

  Monoclonal

• Clone:

  O323

• Conjugation:

  APC-Cy7

• Type:

  Primary Antibodies

• Field of Research:

  Immunology, Apoptosis

• Purification:

  The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.

• Concentration:

  Batch dependent

• Buffer:

  Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  The product should be stored undiluted at 4˚ C and should be protected from prolonged exposure to light. Do not freeze.

• Fragment:

  Mouse IgG1, kappa

• Specificity:

  The O323 monoclonal antibody specifically binds to the human CD27, which is a lymphocyte-specific member of the TNF/NGF-R family, expressed on a subset of human thymocytes and the majority of the mature T cells.

• Symbol:

  CD27

• NCBI Official Name:

  CD27 molecule

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Hendriks, J., Xiao, Y., Borst, J. (2003) . CD27 promotes survival of activated T cells and complements CD28 in generation and establishment of the effector T cell pool.The Journal of experimental medicine,198 (9), 1369-1380.

• Background Reference 02:

  Sakanishi, T., Yagita, H. (2010) . Anti-tumor effects of depleting and non-depleting anti-CD27 monoclonal antibodies in immune-competent mice.Biochemical and biophysical research communications,393 (4), 829-835.

• Background Reference 03:

  Gravestein, L. A., Nieland, J. D., Kruisbeek, A. M., Borst, J. (1995) . Novel mAbs reveal potent co-stimulatory activity of murine CD27.International immunology,7 (4), 551-557.

• Other Product Names:

  T14, S152, Tp55, TNFRSF7, S152. LPFS2, CD27

• Tested Applications:

  Flow

• Physical Properties:

  Liquid