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CD45.2 Antibody [104]

CAT: 0223-76-551Size: 0.1 mgDry Ice: NoHazardous: No
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CAT#:0223-76-551Size:0.1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
The 104 monoclonal antibody specifically reacts with the mouse CD45 molecule, the Leukocyte Common Antigen (LCA) which occurs in the alloantigen CD45.2-expressing mouse strains (C57BL/6, CBA, 129, A, AKR, C58, DBA/1, DBA/2, BALB/c, and C3H/He) . The 104 monoclonal antibody does not react with the leukocytes of the CD45.1-expressing mouse strains (DA, SJL/J, RIII, and STS/A) . The CD45 molecule is a member of the Protein Tyrosine Phosphatase (PTP) family, because its intracellular region contains two PTP domains. The extracellular region’s variability is caused by different levels of glycosylation, and the splicing of the 4, 5, and 6 exons. The isoforms found in the mouse strains depend on the activation state, maturation stage and cell type, and are very important in B and T lymphocytes antigen receptor signal transduction. The 104 antibody inhibits some of the B lymphocytes responses, reduces the serum IgG levels, and influences the autoimmune renal pathology.
NCBI Gene ID
19264
Swiss Prot
P06800
Host
Mouse
Reactivity
Mouse
Clonality
Monoclonal
Clone
104
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Immunology
Purification
The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.
Concentration
Batch dependent
Buffer
Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
The product should be stored undiluted at 4˚ C and should be protected from prolonged exposure to light. Do not freeze.
Fragment
Mouse IgG2a, kappa
Specificity
The 104 monoclonal antibody specifically reacts with the mouse CD45 molecule, the Leukocyte Common Antigen (LCA) which occurs in the alloantigen CD45.2-expressing mouse strains (C57BL/6, CBA, 129, A, AKR, C58, DBA/1, DBA/2, BALB/c, and C3H/He) .
Symbol
Ptprc
NCBI Official Name
Protein tyrosine phosphatase, receptor type, C
NCBI Organism
Mus musculus
Background Reference 01
Shen, F. W., Tung, J. S., Boyse, E. A. (1986) . Further definition of the Ly-5 system.Immunogenetics,24 (3), 146-149.
Background Reference 02
Shen, F.W. (1981) Monoclonal antibodies to mouse lymphocyte differentiation alloantigens. Monoclonal Antibodies and T-Cell Hybridomas: Perspectives and Technical Advances. G.J. H U. H and J.F. Kearney, editors. Elsevier/North-Holland, Amsterdam. pp. 2531.
Background Reference 03
Yakura, H., Shen, F. W., Bourcet, E., Boyse, E. A. (1983) . On the function of Ly-5 in the regulation of antigen-driven B cell differentiation. Comparison and contrast with Lyb-2.The Journal of experimental medicine,157 (4), 1077-1088.
Background Reference 04
Suzuki, K., Oida, T., Hamada, H., Hitotsumatsu, O., Watanabe, M., Hibi, T., ... Ishikawa, H. (2000) . Gut cryptopatches: direct evidence of extrathymic anatomical sites for intestinal T lymphopoiesis.Immunity,13 (5), 691-702.
Other Product Names
Loc, B220, Cd45, L-CA, Ly-5, T200, CD45R, Lyt-4, Ptprc
Tested Applications
Flow, IHC, ICC, IP
Physical Properties
Liquid

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Alternative Products

CatalogName
HY-P990268Anti-Mouse CD45.2 Antibody (104.2)
QAB43-PE-25ugAnti-CD45.2 Antibody [104], PE-25ug
QAB43-APC-25ugAnti-CD45.2 Antibody [104], APC-25ug
QAB43-F-100ugAnti-CD45.2 Antibody [104], FITC-100ug
QAB43-F-25ugAnti-CD45.2 Antibody [104], FITC-25ug
QAB43-V450-25ugAnti-CD45.2 Antibody [104], V450-25ug
QAB43-F-500ugAnti-CD45.2 Antibody [104], FITC-500ug
QAB43-APC-100ugAnti-CD45.2 Antibody [104], APC-100ug
QAB43-PE-100ugAnti-CD45.2 Antibody [104], PE-100ug
QAB43-V450-100ugAnti-CD45.2 Antibody [104], V450-100ug

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