CD25 Antibody [BC96]

• Background:

  The BC96 monoclonal antibody specifically reacts with the 55 kDa type I transmembrane glycoprotein known as the interleukin-2 receptor alpha (IL-2R alpha, also known as CD25) . CD25 is expressed by the early progenitors of T and B lymphocytes lineage, and by activated mature T and B lymphocytes. CD25 is a low affinity interleukin-2 receptor, but its association with the IL-2 receptor beta chain (CD122) and the common gamma chain (CD 132) results in a high affinity IL-2R complex. CD25 plays an important role in B and T cell proliferation, differentiation, and activation.

• NCBI Gene ID:

  3559

• Swiss Prot:

  P01589

• Host:

  Mouse

• Reactivity:

  Human

• Clonality:

  Monoclonal

• Clone:

  BC96

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Immunology

• Purification:

  The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.

• Concentration:

  Batch dependent

• Buffer:

  Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  The product should be stored undiluted at 4˚ C and should be protected from prolonged exposure to light. Do not freeze.

• Fragment:

  Mouse IgG1, kappa

• Specificity:

  The BC96 monoclonal antibody specifically reacts with the 55 kDa type I transmembrane glycoprotein known as the interleukin-2 receptor alpha (IL-2R alpha, also known as CD25) .

• Symbol:

  IL2RA

• NCBI Official Name:

  Interleukin 2 receptor, alpha

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Schlossman, S., L. Bloumsell, et al. eds (1995) . Leucocyte Typing V: White Cell Differentiation Antigens. Oxford University Press. New York

• Background Reference 02:

  Zhang, B., Zhang, X., Tang, F. L., Zhu, L. P., Liu, Y., Lipsky, P. E. (2008) . Clinical significance of increased CD4+ CD25 Foxp3+ T cells in patients with new-onset systemic lupus erythematosus.Annals of the rheumatic diseases,67 (7), 1037-1040.

• Background Reference 03:

  Chapel, A., Bensussan, A., Vilmer, E., Dormont, D. (1992) . Differential human immunodeficiency virus expression in CD4+ cloned lymphocytes: from viral latency to replication.Journal of virology,66 (6), 3966-3970.

• Other Product Names:

  P55, CD25, IL2R, TCGFR, IDDM10, IL2RA

• Tested Applications:

  Flow

• Physical Properties:

  Liquid