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CD25 Antibody [BC96]

CAT: 0223-76-499Size: 0.1 mgDry Ice: NoHazardous: No
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CAT#:0223-76-499Size:0.1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
The BC96 monoclonal antibody specifically reacts with the 55 kDa type I transmembrane glycoprotein known as the interleukin-2 receptor alpha (IL-2R alpha, also known as CD25) . CD25 is expressed by the early progenitors of T and B lymphocytes lineage, and by activated mature T and B lymphocytes. CD25 is a low affinity interleukin-2 receptor, but its association with the IL-2 receptor beta chain (CD122) and the common gamma chain (CD 132) results in a high affinity IL-2R complex. CD25 plays an important role in B and T cell proliferation, differentiation, and activation.
NCBI Gene ID
3559
Swiss Prot
P01589
Host
Mouse
Reactivity
Human
Clonality
Monoclonal
Clone
BC96
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Immunology
Purification
The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.
Concentration
Batch dependent
Buffer
Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
The product should be stored undiluted at 4˚ C and should be protected from prolonged exposure to light. Do not freeze.
Fragment
Mouse IgG1, kappa
Specificity
The BC96 monoclonal antibody specifically reacts with the 55 kDa type I transmembrane glycoprotein known as the interleukin-2 receptor alpha (IL-2R alpha, also known as CD25) .
Symbol
IL2RA
NCBI Official Name
Interleukin 2 receptor, alpha
NCBI Organism
Homo sapiens
Background Reference 01
Schlossman, S., L. Bloumsell, et al. eds (1995) . Leucocyte Typing V: White Cell Differentiation Antigens. Oxford University Press. New York
Background Reference 02
Zhang, B., Zhang, X., Tang, F. L., Zhu, L. P., Liu, Y., Lipsky, P. E. (2008) . Clinical significance of increased CD4+ CD25 Foxp3+ T cells in patients with new-onset systemic lupus erythematosus.Annals of the rheumatic diseases,67 (7), 1037-1040.
Background Reference 03
Chapel, A., Bensussan, A., Vilmer, E., Dormont, D. (1992) . Differential human immunodeficiency virus expression in CD4+ cloned lymphocytes: from viral latency to replication.Journal of virology,66 (6), 3966-3970.
Other Product Names
P55, CD25, IL2R, TCGFR, IDDM10, IL2RA
Tested Applications
Flow
Physical Properties
Liquid

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