CD14 Antibody [61D3] (FITC)

• Background:

  The 61D3 monoclonal antibody specifically reacts with CD14, a cell surface anchored glycoprotein that is primarily expressed on monocytes, inerfollicular macrophages, and a subset of dendritic cells. CD14 associates with MD-2 (LY-96) and TLR4 to form a receptor complex, which signals specifically in response to bacterial lipopolysaccharide (LPS) binding. The CD14/MD-2/TLR4 receptor complex signals via MyD88, TIRAP, and TRAF6, and ultimately activates NF-kappaB.

• NCBI Gene ID:

  929

• Swiss Prot:

  P08571

• Host:

  Mouse

• Reactivity:

  Human

• Clonality:

  Monoclonal

• Clone:

  61D3

• Conjugation:

  FITC

• Type:

  Primary Antibodies

• Field of Research:

  Innate Immunity

• Purification:

  The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.

• Concentration:

  Batch dependent

• Buffer:

  Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  The product should be stored undiluted at 4˚ C and should be protected from prolonged exposure to light. Do not freeze.

• Fragment:

  Mouse IgG1, kappa

• Specificity:

  The 61D3 monoclonal antibody specifically reacts with CD14, a cell surface anchored glycoprotein that is primarily expressed on monocytes, inerfollicular macrophages, and a subset of dendritic cells.

• Symbol:

  CD14

• NCBI Official Name:

  CD14 molecule

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Schlossman, S. F. (1995) .Leucocyte typing V: White cell differentiation antigens: Proceedings of the Fifth International Workshop and Conference, Held in Boston, USA 3-7 November, 1993. Oxford University Press.

• Background Reference 02:

  Leucocyte Typing VI: White Cell Differentiation Antigens: Proceedings of the Sixth International Workshop and Conference Held in Kobe, Japan, 10-14 November 1996. Garland Pub., 1998.

• Background Reference 03:

  Devitt, A., Moffatt, O. D., Raykundalia, C., Capra, J. D., Simmons, D. L., Gregory, C. D. (1998) . Human CD14 mediates recognition and phagocytosis of apoptotic cells.Nature,392 (6675), 505-509.

• Other Product Names:

  CD14, CD14

• Tested Applications:

  Flow

• Physical Properties:

  Liquid