CD4 Antibody [RPA-T4] (PE)

• Background:

  The RPA-T4 monoclonal antibody specifically binds to the CD4 receptor for the human immunodeficiency virus (HIV) . CD4 is a 59 kDa single-chain transmembrane glycoprotein that expressed on the surface of most of the thymocytes, T-helper cells, and in low levels on monocytes and macrophages. CD4 is a co-receptor in the antigen-induced T cell activation, together with the MHC class II. The RPA-T4 antibody is capable of blocking HIV binding and inhibiting syncytium formation, by binding to the D1 domain of the CD4 antigen. The OKT4 and the RPA-T4 monoclonal antibodies recognize different epitopes of CD4 and they do not exhibit cross-block binding.

• NCBI Gene ID:

  920

• Swiss Prot:

  P01730

• Host:

  Mouse

• Reactivity:

  Human

• Clonality:

  Monoclonal

• Clone:

  RPA-T4

• Conjugation:

  PE

• Type:

  Primary Antibodies

• Field of Research:

  Immunology

• Purification:

  The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.

• Concentration:

  Batch dependent

• Buffer:

  Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  The product should be stored undiluted at 4˚ C and should be protected from prolonged exposure to light. Do not freeze.

• Fragment:

  Mouse IgG1, kappa

• Specificity:

  The RPA-T4 monoclonal antibody specifically binds to the CD4 receptor for the human immunodeficiency virus (HIV) .

• Symbol:

  CD4

• NCBI Official Name:

  CD4 molecule

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Knapp W (1989) Leucocyte typing IV: white cell differentiation antigens. Oxford University Press, 1989.

• Background Reference 02:

  Schlossman, S., L. Bloumsell, et al. eds (1995) . Leucocyte Typing V: White Cell Differentiation Antigens. Oxford University Press. New York

• Other Product Names:

  CD4mut, CD4

• Tested Applications:

  Flow

• Physical Properties:

  Liquid