CD3 Antibody [17A2] (PE)

• Background:

  The 17A2 monoclonal antibody specifically reacts with the MouseT lymphocytes receptor (TCR) associated CD3 complex, resulting in cellular activation and proliferation. CD3 is expressed by thymocytes and mature lymphocytes, and contains gamma, delta, and epsilon subunits, involved in the assembly, trafficking, and surface expression of T-cell receptor complex. The interaction between the T lymphocytes and the 17A2 antibody can be blocked by the 145-2C11 anti-CD3e antibody, demonstrating that the 17A2 antibody recognizes the CD3 epsilon chain.

• NCBI Gene ID:

  12501

• Swiss Prot:

  P22646

• Host:

  Rat

• Reactivity:

  Mouse

• Clonality:

  Monoclonal

• Clone:

  17A2

• Conjugation:

  PE

• Type:

  Primary Antibodies

• Field of Research:

  Immunology

• Purification:

  The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.

• Concentration:

  Batch dependent

• Buffer:

  Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  The product should be stored undiluted at 4˚ C and should be protected from prolonged exposure to light. Do not freeze.

• Fragment:

  Rat IgG2b, kappa

• Specificity:

  The 17A2 monoclonal antibody specifically reacts with the MouseT lymphocytes receptor (TCR) associated CD3 complex, resulting in cellular activation and proliferation.

• Symbol:

  Cd3e

• NCBI Official Name:

  CD3 antigen, epsilon polypeptide

• NCBI Organism:

  Mus musculus

• Background Reference 01:

  Miescher, G. C., Schreyer, M., MacDonald, H. R. (1989) . Production and characterization of a rat monoclonal antibody against the murine CD3 molecular complex.Immunology letters,23 (2), 113-118.

• Background Reference 02:

  Mysliwietz, J., Thierfelder, S. (1992) . Antilymphocytic antibodies and marrow transplantation. XII. Suppression of graft-versus-host disease by T-cell-modulating and depleting antimouse CD3 antibody is most effective when preinjected in the marrow recipient.Blood,80 (10), 2661-2667.

• Background Reference 03:

  Wu, L., Antica, M., Johnson, G. R., Scollay, R., Shortman, K. (1991) . Developmental potential of the earliest precursor cells from the adult mouse thymus.The Journal of experimental medicine,174 (6), 1617-1627.

• Other Product Names:

  CD3, T3e, AI504783, CD3epsilon, Cd3e

• Tested Applications:

  Flow

• Physical Properties:

  Liquid