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CD3 Antibody [Hit3a]

CAT: 0223-76-213Size: 0.1 mgDry Ice: NoHazardous: No
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CAT#:0223-76-213Size:0.1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
The Hit3a monoclonal antibody specifically reacts with the epsilon chain of the CD3/T lymphocyte antigen receptor complex. The CD3 complex is part of the TCR complex, expressed by all mature T lymphocytes and by the thymocyte lineage. CD3 enhances the antigen recognition by signal transduction.The HIT3a antibody cross-links with the TCR complex, initiating the cellular activation and proliferation, but it cannot be used for intracellular CD3 staining, as it is able to stain only the surface CD3 complex.
NCBI Gene ID
916
Swiss Prot
P07766
Host
Mouse
Reactivity
Human
Clonality
Monoclonal
Clone
Hit3a
Conjugation
Unconjugated
Type
Primary Antibodies, Functional Antibodies
Field of Research
Immunology
Purification
The monoclonal antibody was purified utilizing affinity chromatography.
Concentration
Batch dependent
Buffer
Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
The product should be stored undiluted at 4˚ C . Do not freeze.
Fragment
Mouse IgG2a, kappa
Specificity
The Hit3a monoclonal antibody specifically reacts with the epsilon chain of the CD3/T lymphocyte antigen receptor complex.
Symbol
CD3E
NCBI Official Name
CD3e molecule, epsilon (CD3-TCR complex)
NCBI Organism
Homo sapiens
Background Reference 01
McMichael, A. J. (1987) . Leucocyte typing III.Oxford University Press, Oxford. Norton AJ, Isaacson PG (1985)
Background Reference 02
Knapp W (1989) Leucocyte typing IV: white cell differentiation antigens. Oxford University Press, 1989.
Background Reference 03
Schlossman, S., L. Bloumsell, et al. eds (1995) . Leucocyte Typing V: White Cell Differentiation Antigens. Oxford University Press. New York
Background Reference 04
Lanier, L. L., Allison, J. P., Phillips, J. H. (1986) . Correlation of cell surface antigen expression on human thymocytes by multi-color flow cytometric analysis: implications for differentiation.The Journal of Immunology,137 (8), 2501-2507.
Other Product Names
T3E, TCRE, IMD18, CD3E
Tested Applications
Flow, Functional Assays, IHC, IP
Physical Properties
Liquid

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