CD90.2 Antibody [30-H12] (FITC)

• Background:

  The 30-H12 monoclonal antibody specifically binds to MouseCD90.2, an alloantigen known as Thy-1.2, expressed on thymocytes, mature T cells, epithelial cells, neurons, hematopoietic stem cells, and fibroblasts. CD90 is a membrane glycoprotein that regulates the adhesion and signal transduction in T lymphocytes, and the adhesion of thymocytes to thymic stroma. The interaction between 30-H12 and the antibody to the CD3/TCR complex upregulates thymocytes signal transduction and apoptosis and downregulates mature T cell proliferation. The 30-H12 antibody seems to be unable to cross-link with CD90.1.

• NCBI Gene ID:

  21838

• Swiss Prot:

  P01831

• Host:

  Rat

• Reactivity:

  Mouse

• Clonality:

  Monoclonal

• Clone:

  30-H12

• Conjugation:

  FITC

• Type:

  Primary Antibodies

• Field of Research:

  Immunology

• Purification:

  The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.

• Concentration:

  Batch dependent

• Buffer:

  Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  The product should be stored undiluted at 4˚ C and should be protected from prolonged exposure to light. Do not freeze.

• Fragment:

  Rat IgG2b

• Specificity:

  The 30-H12 monoclonal antibody specifically binds to MouseCD90.2, an alloantigen known as Thy-1.

• Symbol:

  Thy1

• NCBI Official Name:

  Thymus cell antigen 1, theta

• NCBI Organism:

  Mus musculus

• Background Reference 01:

  Ledbetter, J. A., Herzenberg, L. A. (1979) . Xenogeneic Monoclonal Antibodies to Mouse Lymphoid Differentiation Antigens*.Immunological reviews,47 (1), 63-90.

• Background Reference 02:

  Radrizzani, M., Carminatti, H., Pivetta, O. H., Vargas, V. P. (1995) . Developmental regulation of Thy 1.2 rate of synthesis in the mouse cerebellum.Journal of neuroscience research,42 (2), 220-227.

• Background Reference 03:

  Seaman, W. E., Wofsy, D., Greenspan, J. S., Ledbetter, J. A. (1983) . Treatment of autoimmune MRL/Ipr mice with monoclonal antibody to Thy-1.2: a single injection has sustained effects on lymphoproliferation and renal disease.The Journal of Immunology,130 (4), 1713-1718.

• Other Product Names:

  T25, CD90, Thy-1, Thy1.1, Thy1.2, Thy-1.2, Thy1

• Tested Applications:

  Flow

• Physical Properties:

  Liquid